Volume 28, Issue 10 (12-2021)                   RJMS 2021, 28(10): 0-0 | Back to browse issues page

Research code: با تایید دانشگاه علوم پزشکی بقیه ا... (عج)
Ethics code: با تایید دانشگاه علوم پزشکی بقیه ا... (عج)
Clinical trials code: با تایید دانشگاه علوم پزشکی بقیه ا... (عج)

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Rahimi M, Nowroozi M, Asad M R, hemati farsani Z. Effects of High Intensity Interval Training and Moderate-Intensity Continuous Training on Brain-Derived Neurotrophic (BDNF) and Insulin-like Growth-1 (IGF-1) in Wistar Male Rat. RJMS. 2021; 28 (10)
URL: http://rjms.iums.ac.ir/article-1-6345-en.html
exercise physiology, Shahrekord University, Shahrekord, Iran , hematyn.sport87@yahoo.com
Abstract:   (126 Views)
Background: Physical activity has benefits on cognitive function and some evidence suggests that brain-derived neural growth factor (BDNF) and insulin-like growth factor-1 (IGF1) play a role in this effect, so the aim of the present study was comparision of two types of high intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on BDNF and IGF1 in male Wistar rats
Methods: This experimental study was done on 32 Wistar male rats (an average weight of 235 grams). They were randomly divided into four groups include MICT, HIIT, Control, Control 8 weeks. The training program included 8 weeks, five sessions per week, and each session with four-seven periods of one minutes activity at high speeds of 28-55 m/mins and low speed of 15 to 30 m / min and continuous training at 15 to 30 m / min and duration of each session 15 to 60 minutes using a rodent treadmill. After the last exercise period, circulating levels of BDNF and IGF-1 were measured by ELISA method and one-way ANOVA test were used for data analysis; and the significant level was set at p>0.05.
Results: Results showed the significant difference in serum IGF-1 levels after last session exercise (P=0.001) as compare to the control group. However, BDNF results wasn’t significant after the exercise between the groups (P=0.93).
Conclusion: In response to endurance exercise the amount of IGF-1 significantly difference after the exercise but there was no significant change in the level of BDNF. It seem that endurance exercise causes positive changes in the amount of neurotrophic factor involved in learning and memory. Subsequently, it is recommended that exercise training improve cognitive status.
Type of Study: Research | Subject: Exercise Physiology

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