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Abstract: (263 Views)
Transplantation of adult hepatocytes extracted from the liver has important effects in the treatment process, but the number of functionally active hepatocytes is very low. Human embryonic stem cells can be transformed into a wide range of cell types in laboratory conditions. Some studies have also shown that these cells have the potential to transform into hepatocytes or hepatocyte-like cells. Hepatogenic differentiation using mesenchymal stem cells derived from other tissues such as bone marrow, adipose tissue, umbilical cord blood and placenta has been considered in order to increase the efficiency of hepatogenic differentiation using simple methods. The use of stem cells appears to be a potential treatment for liver disorders. Clinical trials using mesenchymal stem cells show improvement of liver function and reduction of complications caused by liver disorders in patients with chronic hepatitis B. With the advancement of medical science, the use of mesenchymal stem cells in the healing and repair of liver damage has been considered. The mechanism of action of these cells is still unknown, but they may be able to prevent the progression of liver damage and improve liver function. While migrating to the damaged areas, these cells are divided and can differentiate into different types of cells. By modulating the immune system, these cells produce a series of effective paracrine factors. The effectiveness of treatments based on mesenchymal stem cells in liver damage has also been investigated in animal models. However, more extensive clinical studies are needed to confirm the safety and efficacy of this treatment method in humans. In this review article, we will examine the functions and therapeutic effects of mesenchymal stem cells on liver diseases.
Type of Study: review article |
Subject:
Biology
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