Background: The purpose of the present study was to determine the effect of resistance training on atrogin, eotaxin and IL-10 indices in obese women. Methods: In this semi-experimental study, 30 obese women aged 30-45 years for South Tehran Branch Islamic Azad University were selected and divided into two groups of resistance training (n = 10) and control (n = 10). In the pre-test, and 24 hours before the start of the exercise, the individual characteristics of the subjects and the research variables (atrogin, eotaxin and IL-10) were measured in blood. Subsequently, the subjects in the resistance training group performed their training program, which was initially 1RM using the Brazilian formula. Subjects then began their workouts for 8 weeks, three sessions per week at 40% intensity and 5 repetitions in the first week, and the intensity gradually increased to reach 90% at week 20 with 20 repetitions. Data were analyzed using dependent t-test, two-way ANOVA, and Bonferroni test. Results: The results showed that a period of resistance training had no significant effect on the level of atrogin and eotaxin in obese women but had a significant effect on IL-10 level. Conclusion: Regarding the lack of significant effect of resistance training on atherogenic and etotoxin, it is recommended that obese women use resistance training in consultation with physician.
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