Volume 26, Issue 8 (11-2019)
RJMS 2019, 26(8): 56-67 |
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Bagheri-Mohammadi S, Noureddini M, Alani B. Stem cell therapies as potential candidates in Parkinson's disease treatment. RJMS 2019; 26 (8) :56-67
URL: http://rjms.iums.ac.ir/article-1-5664-en.html
URL: http://rjms.iums.ac.ir/article-1-5664-en.html
PhD Student in Medical Physiology, Department of Physiology and Neurophysiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , bagherimohammadi-sa@sbmu.ac.ir
Abstract: (4039 Views)
Background: Treatment of Parkinson’s Disease (PD) has an important aim for the physicians, patients and families, and for the society. The experimental research by cell therapy for PD has commonly used stem cells as the donor source. Human Endometrial Derived Stem Cells (HEDSCs), a readily obtainable type of mesenchymal stem-like cell was used to generate Dopaminergic (DA) neurons. The aim of this study was to investigate the therapeutic effect of intranasal administration of endometrial stem cells in mouse model of PD.
Methods: In this investigation, for evaluation therapeutic efficacy of intranasal administration of HEDSCs in 6-OHDA induced mouse model of PD, 28 male mice weighting 25-30 gr were divided into 4 groups. On days 30, 60, 90, and 120 post stem cells administrated, the rotational behavior was measured. The animal received an intraperitoneal injection of apomorphine (0.5 mg/kg), and was placed in an opaque cylinder. Also, to evaluate differentiation of HEDSCs in to the neural cells in mice brain, immunohistochemistry staining by using human neural Nesti was performed.
Results: The result indicated that the intranasal administration of HEDSCs could decrease rotational behavioral compared with control group significantly post cell therapy in mouse model of PD. Besides, endometrial stem cells could differentiate into neural cells.
Methods: In this investigation, for evaluation therapeutic efficacy of intranasal administration of HEDSCs in 6-OHDA induced mouse model of PD, 28 male mice weighting 25-30 gr were divided into 4 groups. On days 30, 60, 90, and 120 post stem cells administrated, the rotational behavior was measured. The animal received an intraperitoneal injection of apomorphine (0.5 mg/kg), and was placed in an opaque cylinder. Also, to evaluate differentiation of HEDSCs in to the neural cells in mice brain, immunohistochemistry staining by using human neural Nesti was performed.
Results: The result indicated that the intranasal administration of HEDSCs could decrease rotational behavioral compared with control group significantly post cell therapy in mouse model of PD. Besides, endometrial stem cells could differentiate into neural cells.
Type of Study: Research |
Subject:
Physiology
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