Volume 26, Issue 6 (9-2019)                   RJMS 2019, 26(6): 44-53 | Back to browse issues page

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Ardeshiri M, Zia Jahromi N. The effect of Chartine on expression of Pdx1 gene in streptozotocin-induced diabetic rats. RJMS 2019; 26 (6) :44-53
URL: http://rjms.iums.ac.ir/article-1-5612-en.html
Shahrekord Branch Islamic Azad University, Shahrekord, Iran , n.zia@iaushk.ac.ir
Abstract:   (2660 Views)
Background: Pdx1 is a transcription factor that plays a key role in pancreatic development and regulation of insulin gene expression and the aim of the present study was to evaluate the effect of pregnancy on the treatment of diabetes-induced liver disease and the expression of the Pdx1 gene, an apoptotic gene, and in the event of damage to the anti-apoptotic activity.
Methods: In this experimental study, 42 adult male Wistar rats were randomly divided into 7 healthy control groups, diabetic control, control group, Chartine 150 mg / kg controls, and Three groups received the effective dose of the Chartine (50, 100 and 200 mg / kg). All groups except diabetic control group and control group with streptozotocin chemical injected intraperitoneally. Afterwards, they received a cartilage by gavage for four weeks. At the end, the data were evaluated statistically.
Results: According to the obtained data, it can be concluded that the lowest expression is related to the diabetic group (C) and the highest expression among the groups receiving different doses of the Chartine was related to the dose of 100 (F), and the least relevant dose was 50 (E).
Conclusion: Evidence suggests that increased expression of the Pdx1 gene was not dose-dependent. After the development of diabetes, the patient's severity declined sharply, and after the use of chronitin and metformin, this reduction was some what offset.
 
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Type of Study: Research | Subject: Biology

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