Volume 25, Issue 9 (12-2018)                   RJMS 2018, 25(9): 57-66 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Pourmokhtar Neyshabori Z, Heydari H, Sagharjoghi Farahani M, Goodarzi A, Badripour A. The Effects of T4 Thyroid Hormone Proliferation on U87 Brain Glioblastoma Cells. RJMS 2018; 25 (9) :57-66
URL: http://rjms.iums.ac.ir/article-1-5285-en.html
Islamshahr Branch, Islamic Azad University, Islamshahr, Iran , m.farahani@iaups.ac.ir
Abstract:   (2633 Views)
Background: Considering the effect of thyroid hormone on cancer cells, as well as the development of hormonal therapies for cancer cells. The aim of this study was to investigate the effects of cytotoxic thyroid hormones T4 on proliferation of brain glioblastoma cells (U87) in cell culture.
Methods: In this laboratory experimental study, U87 cells were randomly divided into control group and groups exposed to doses 0.1, 0.5, 1, 5, 10, 20, 40, 50 Lambda (λ) of thyroid hormones T4. The toxic effect of hormones was measured using MTT assay method. The data were statistically analyzed between groups using ANOVA and SPSS.
Results: The results show that the survival of U87 cells at doses of 0.5 λ of thyroid hormone T4 at 3 times of 24, 48 and 72 hours compared with other groups in different doses had the least toxic effect. Also survival of cells at 5 λ dose of thyroid hormone T4 at 24, 48 and 72 hours compared to other groups had the highest toxicity.
Conclusion: Toxicity of glioblastoma cells is not dependent on thyroid hormone (T4), and results of this study showed that thyroid hormone does not affect U87 glioblastoma cells.
Full-Text [PDF 681 kb]   (940 Downloads)    
Type of Study: Research | Subject: Endocrinology

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Razi Journal of Medical Sciences

Designed & Developed by : Yektaweb