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Islamic Azad University , m.farahani@iaups.ac.ir
Abstract:   (63 Views)
Background & Objectives:
Considering the effects of thyroid hormone on cancer cells, as well as the development of hormonal therapies for cancer cells. The main aim of this study was to investigate the effects of Cytotoxic Thyroid hormones T4 on Proliferation of Brain Glioblastoma Cells (U87) in Cell Culture Cell Culture.
Materials and Methods:
In this laboratory experimental study, U87 cells were randomly divided into control group and groups exposed doses to 0.1, 0.5, 1, 5, 10, 20, 40, 50 Lambda (λ) of Thyroid Hormones T4. The toxic effect of hormones was measured using MTT assay method. The data were statistically analyzed between groups using ANOVA and SPSS.
The results show that the survival of U87 cells at doses of 0.5 λ of thyroid hormone T4 at 3 times of 24, 48 and 72 hours compared with other groups in different doses has the least toxic effect., As well as survival of cells at 5 λ dose of thyroid hormone T4 at 24, 48 and 72 hours, compared to other groups with the highest toxicity.
Toxicity is a non-thyroid hormone-dependent glioblastoma cell (4T), which results in this study suggesting that thyroid hormone does not affect U87's glioblastoma cells.
Type of Study: Research | Subject: Endocrinology

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