Volume 24, Issue 165 (3-2018)
RJMS 2018, 24(165): 66-76 |
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Khodadadi D, Gharakhanlou R, Naghdi N, Salimi M, Azimi S M, Shahed A. The effect of 4 weeks of exercise preconditioning on soluble amyloid beta level and memory impairment in rats with Alzheimer's disease induced by Aβ1-42 injection . RJMS 2018; 24 (165) :66-76
URL: http://rjms.iums.ac.ir/article-1-5023-en.html
URL: http://rjms.iums.ac.ir/article-1-5023-en.html
Davar Khodadadi 
, Reza Gharakhanlou , Naser Naghdi , Mona Salimi , Seyyed Mohammad Azimi , Atabak Shahed
, Reza Gharakhanlou , Naser Naghdi , Mona Salimi , Seyyed Mohammad Azimi , Atabak Shahed
Tarbiat Moddaress University, Tehran, Iran. , ghara_re@modares.ac.ir
Abstract: (5183 Views)
Background: Alzheimer's disease (AD) is the most common form of dementia and amyloid peptides playing a central role in its pathogenesis. Recently, regular exercise has been considered as one of the most important non-pharmacological mechanisms to contrast with AD. Therefore, the aim of the present study was to investigate the effect of 4 weeks of exercise preconditioning on the level of soluble amyloid and memory impairment in rats with AD induced by Aβ1-42 injection.
Methods: Eighty four male rats with mean±SD weight of 195±20 g were randomly divided into two groups of aerobic training or resting for 4 weeks. Then, each group was subdivided into 3 subgroups of AD, sham and non-injected. Forty eight hours after the last training session, injection of Aβ1-42 or DMSO into the hippocampus was performed. Seven days after surgery, rats of each groups were either sacrificed (7 rats) or subjected to behavioral testing (7 rats), randomly. Following the collection of blood samples in the victim's rats, the hippocampal tissue was extracted and the levels of Aβ1-42 in plasma and hippocampus, as well as the plasma level of the soluble Low-Density Lipoprotein Receptor-Related Protein-1 (sLRP-1) evaluated.
Results: The results showed that in the exercise + AD group, hippocampal level of Aβ1-42 were lower, and plasma level of Aβ1-42 were higher than the AD group (p<0.001). Plasma sLRP-1 level in the exercise + AD group was also greater than the AD group (p<0.001). Moreover, spatial learning and memory were significantly better in the exercise + AD than AD group (p<0.01).
Conclusion: It seems that 4 weeks of exercise preconditioning could reduce the loss of spatial learning and memory through increasing soluble amyloid beta clearance from the brain.
Methods: Eighty four male rats with mean±SD weight of 195±20 g were randomly divided into two groups of aerobic training or resting for 4 weeks. Then, each group was subdivided into 3 subgroups of AD, sham and non-injected. Forty eight hours after the last training session, injection of Aβ1-42 or DMSO into the hippocampus was performed. Seven days after surgery, rats of each groups were either sacrificed (7 rats) or subjected to behavioral testing (7 rats), randomly. Following the collection of blood samples in the victim's rats, the hippocampal tissue was extracted and the levels of Aβ1-42 in plasma and hippocampus, as well as the plasma level of the soluble Low-Density Lipoprotein Receptor-Related Protein-1 (sLRP-1) evaluated.
Results: The results showed that in the exercise + AD group, hippocampal level of Aβ1-42 were lower, and plasma level of Aβ1-42 were higher than the AD group (p<0.001). Plasma sLRP-1 level in the exercise + AD group was also greater than the AD group (p<0.001). Moreover, spatial learning and memory were significantly better in the exercise + AD than AD group (p<0.01).
Conclusion: It seems that 4 weeks of exercise preconditioning could reduce the loss of spatial learning and memory through increasing soluble amyloid beta clearance from the brain.
Type of Study: Research |
Subject:
Exercise Physiology
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