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Khodadadi D, Gharakhanlou R, Naghdi N, Salimi M, Azimi S M, Shahed A. The effect of 4 weeks of exercise preconditioning on soluble amyloid beta level and memory impairment in rats with Alzheimer's disease induced by Aβ1-42 injection . RJMS. 2018; 24 (165)
URL: http://rjms.iums.ac.ir/article-1-5023-en.html
Professor Tarbiat Moddaress University
Abstract:   (163 Views)
Alzheimer's disease (AD) is the most common form of dementia. Amyloid peptides playing a central role in AD pathogenesis. Recently, regular exercise has been considered as one of the most important non-pharmacological mechanisms to contrast with AD. Therefore, the aim of the present study was to investigate the effect of 4 weeks of exercise preconditioning on the level of soluble amyloid and memory impairment in rats with AD induced by Aβ1-42 injection. For this purpose, 84 male rats with a mean weight of 195 ± 20 g were randomly divided into two groups of aerobic training or resting for 4 weeks. Then, each group was subdivided into 3 subgroups of AD, sham and non-injected. Forty eight hours after the last training session, injection of Aβ1-42 or DMSO into the hippocampus was performed. Seven days after surgery, rats of each groups were either sacrificed (7 rats) or subjected to behavioral testing (7 rats), randomly. Following the collection of blood samples in the victim's rats, the hippocampal tissue was extracted and the levels of Aβ1-42 in plasma and hippocampus, as well as the plasma level of the soluble Low-Density Lipoprotein Receptor-Related Protein-1 (sLRP-1) evaluated. The results showed that in the exercise + AD group, hippocampal level of Aβ1-42 were lower, and plasma level of Aβ1-42 were higher than the AD group (p <0.001). Plasma sLRP-1 level in the exercise + AD group was greater than the AD group (p <0.001). Learning and spatial memory were significantly better in the exercise + AD than AD group (p <0.01). It seems that 4 weeks of exercise preconditioning could reduce the loss of spatial learning and memory through increasing soluble amyloid beta clearance from the brain.
 
     
Type of Study: Research | Subject: Exercise Physiology

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