Razi Journal of Medical Sciences

*A. Adib, MD B. Fatourchi, MD

There are many different doses and protocols of heparin injection for treatment or prevention of many thrombotic diseases. The present interventional experimental(Clinical trial) study was conducted to compare the effect of continuous and intermittent injection of heparin on APTT at different times. 423 patients were randomly selected by simple sampling and their APTT was measured by a standard and unique kit at predetermined time after injection. The only time in the intermittent method when APTT was in its therapeutic range was 60 to 40 minutes after primary bolus injection. Before that, there were higher and after that lower levels of desired ones whereas in the continuous method there was a near constant level of APTT. The goal of practitioners is to find a drug which is in constant therapeutic range and safe from pharmacokinetic point of view therefore, according to the results of this study, the continuous method of heparin administration is strongly recommended in order to decrease the rate of thrombosis recurrence and complications such as hemorrhage.