Volume 21, Issue 124 (10-2014)                   RJMS 2014, 21(124): 96-102 | Back to browse issues page

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Zabihiyeganeh M, Khiabani E, Nojomi M, Jahed S A. Effect of vitamin D on widespread pain index of fibromyalgia patients. RJMS 2014; 21 (124) :96-102
URL: http://rjms.iums.ac.ir/article-1-3378-en.html
Iran University of Medical Sciences
Abstract:   (16674 Views)

Background: Various studies have reported hypovitaminosis D in Fibromyalgia patients. In the present study, we have evaluated the effect of vitamin D supplements on widespread pain index of fibromyalgia patients.


Methods: The present study was performed from October 2012 to February 2014 in Rheumatology Clinic of Firoozgar Hospital. A total of 74 patients diagnosed as fibromyalgia according to American College of Rheumatology (ACR 2010) criteria who had hypovitaminosis D were selected. Patients were randomized to two groups. Group A received oral vitamin D 50000IU weekly plus trazodone 25 mg at bedtime and group B received trazodone 25 mg at bedtime only.


The patients were evaluated at baseline and 4 and 8 weeks post treatment. At each visit physical examination for tender points and 25 (OH) D level measurement were performed.


Results: About 68.5% of patients with fibromyalgia had hypovitaminosis D. The mean 25(OH) D was 12.4±6.9 ng/ml (11.4±6.5 ng/ml and 13.4±7.3 ng/ml in group A and group B, respectively). There was no significant difference between the two groups at baseline. Comparison between widespread pain index (WPI) scores before and after treatment showed a significant improvement in both groups, 12.2±2.4 at baseline to 4.5±2.5 at week 8 in group A vs. 13.5±3.4 to 8±4.8 in group B. Patients receiving vitamin D showed more improvement than those receiving trazodone only, mean WPI score differences of 7.8±2.8 vs. 5.5±4 respectively, p=0.007.


Conclusion: The present study indicated that treating hypovitaminosis D may improve WPI in Fibromyalgia patients.

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Type of Study: review article | Subject: Internal Medicine

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