Razi Journal of Medical Sciences

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ABSTRACT Helicobacter pylori has a centeral role in the pathogensis of chronic Active gastritis. Infection usually occures during childhood and last for a lifetime. Infectious is a worldwide phenomen but its prevalence is varied. Chronic (Atrophic) gastritis and intestinal metaplasia was accepted as a precursor of intestinal type gastric Carcinoma. Now more searches in the world doing about role of Helicobacter pylori(HP) and stage of Histological Curable for prevention of gastrie Cancer. 2094 specimenfrom Antrum and body of stomach of 576 patients with nonulcer dyspepsia were collected and were studied by cross sectional-descriptive method. 260 (45.1%) were male and 316 (54.9%) were female. Age was between 13 to 89 years old with mean age 48 ± 18.8. overal Hp prevalence was 59.7%, with maximum peak in fifth decade (70.8%). Prevalence of chronic active gastritis, chronic gastritis and intestinal metaplasia was 56.1%, 34.2% and 11.3% respectively. Although Hp in male were 10% more prevalent in female, but prevalence of chronic gastritis and intestinal metaplasia in both sex were equal. prevalence of chronic gastritis and intestinal metaplasia increased with increasing of age and more found beyound of 45 years old. Frequency of Hp Negative in intestinal Metaplasia were higher than HP positive.

Keywords: 1) Prevalence 2) Dyspepsia 3) Helicobacter pylori 4) Metaplasia

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