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URL: http://rjms.iums.ac.ir/article-1-2654-en.html
The nucleus
of mature sperm contains a complex population of transcripts such as mRNAs and
miRNAs which expressed and accumulated during process of spermatogenesis
however in
spermatozoa, transcription is inert. The spermatozoa do not have cytoplasmic ribosomal
compounds and translation apparatus.
However, spermatozoa can translate cytoplasmic mRNAs de novo, using
mitochondrial polysomes. Important roles of spermatozoa RNAs include chromatin
repackaging, paternal genomic imprintingand gene silencing. Recent information of transferred spermatozoa
RNAs into oocytes during fertilization and RNA-mediated epigenetic effect
contribute extra genomically to early embryonic growth.
Furthermore,
regardless of the biological roles of spermatozoal RNA and embryonic growth,
the differences in profile expression of spermatozoa RNAs from fertile and
infertile men, provide potential spermatozoa markers in assessment male
fertility and infertility. In this
review, presence of RNAs in mature sperm, diversity and functions of gene
transcripts in male fertility and embryonic development are discussed.
