Razi Journal of Medical Sciences

During a 14-month period (Dec. 1990-Jan. 1992) , renal biopsies were performed on 105 patients with suspected glomerular disease. All specimens were processed for light microscopy (L.M) and immunoflourescence. Work-up revealed 21 patients to suffer a systemic glomerular disease and glomerular disease was found to be primery in 85 cases.

Predominant IgG deposition was noted in 71 cases with primary glomerular disease and IgA deposition was predominant in 13 cases (15.5%) . Among patients with IgA nephropathy there were 11 males and 2 females, with a mean age of 31 ± 8.3 years (range 18-48). All except one were normotensive .

There was neptuotic range proteinuria in 5 and elevated serum IgA in 9 cases. 24-hour proteinuria was significantly lower among those with IgA nephropathy(3 ± 2.03 g/day vs. 5.87 ± 0.45 g/day, p<0.01). Serum 'lgA was significantly higher among patients with IgA nephropathy(447.4 ± 177 mg/dl vs. 252 ± 118.6 mg/dl, p<0.001). There was only one cases of hypocamplementemia (C₃A9 mgldl). We found FSGN to be the most common pathology reported on LM for those with IgA nephropathy. We concludethatlgA nephropathy is ranther common in our population (15.5% of primary glomerular disease), the prevalence being lower than the Asia-Pacific region, while higher than that reported for North America