Razi Journal of Medical Sciences

  Background: Poor pregnancy outcome and complications like pre-eclampsia, preterm delivery, premature rupture of membranes (PROM) and Intra Uterine Growth Restriction (IUGR) have special importance and finding new methods for their prediction have been always under serious concern. The purpose of the present study is to evaluate the poor pregnancy outcome in nulliparas who had microalbuminuria at the end of second trimester of their pregnancy.

  Methods: The study was conducted as a prospective cohort study on 490 nulliparous women who were at the end of the second trimester of pregnancy. Urine test for albuminuria and creatinine measurement was performed in all women and an albumin creatinine ratio (ACR) was calculated according to milligram per gram. The women were then divided into 3 groups of severe, moderate and mild microalbuminuria according to the ratio. Then the women were followed up to the end of their pregnancy and compared for preterm labor, pre-eclampsia, IUGR and PROM. Statistical analysis was performed using SPSS V.15. Student t - and Chi square tests were used for analysis. P value of less than 0.05 was considered as significant.

  Results: There was no significant difference in regards to BMI, age and age of pregnancy at the time of sampling. Preterm labor {21 (55.26%) cases VS 65 (14.38%), p=0.001}, pre-eclampsia {19 (50%) cases VS 39 (8.62%) cases, p=0.001}, IUGR {15 (39.47%) cases VS 30 (6.63%) cases, p=0.001} and PROM {11 (28.94%) cases VS 47 (10.39%) cases, p=0.001} were more in the case group than control group. Gestational diabetes did not show significant difference between the 2 groups.

  Conclusion: Preterm labor, pre-eclampsia, IUGR and PROM were more in the women who had microalbuminuria at the end of the second trimester of their pregnancy.