Volume 10, Issue 34 (9-2003)
RJMS 2003, 10(34): 195-201 |
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Hesami A, Asgari M, Homayonfar H, Pazoki H. THE ROLE OF ATP SENSITIVE K+ CHANNELS (KATP) ON ISCHEMIA REPERFUSION INDUCED RENAL INJURY IN RATS. RJMS 2003; 10 (34) :195-201
URL: http://rjms.iums.ac.ir/article-1-153-en.html
URL: http://rjms.iums.ac.ir/article-1-153-en.html
Abstract: (10266 Views)
The precise mechanism of ischemia reperfusion (IR) injury is not fully understood. Recent studies on Rat myocardium revealed that activation of the K ATP channels inhibits this process. The goal of this study is finding the same effect of K ATP channels on IR injury, in rat kidney. In this study the effects of K ATP agonist (Diazoxide) and K ATP antagonist (Glibenclamide) plus a K ATP independent vasodilator (Hydralazin) on ischemia reperfusion injury examined. Female rats of 200-250 g were anesthesized and used for study. Different doses of Diazoxide (1, 5, 15mg/kg) and Glibenclamid (1, 5, 10mg/kg) and hydralazin (1, 3, 15mg/kg) were used (SC) 120 minutes prior to the initiation of IR. Kidneys were removed and checked histologically for the grading of injury. Diazoxide (5mg/kg) prevented these lesions. Different doses of Glibenclamide and hydralazine failed to prevent IR injury. Diazoxide is also a vasodilator agent but failure of hydralazine to prevent the injury revealed that vasodilation was not the exact mechanism of action of Diazoxide.
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