Razi Journal of Medical Sciences

  Background & Aim: Hyperthyroidism is one of the important and common diseases of endocrine glands.Since nowadays many people in the world suffer from hyperthyroidism, it imposes economic load upon societies. According to epidemiological studies and existing evidence and papers, hyperthyroidism has significant effects on the metabolism of various organs especially renal function.Therefore, the main purpose of this study is that we believe evaluation of renal function which has an important role in filtering metabolic waste can be clinically useful.This research has been done to evaluate renal function in patients with hyperthyroidism and normal individuals referred to Bu Ali laboratory in Zanjan city.

  Patients and Method: In this case-control study, BUN & creatinine indices in two groups of patients with hyperthyroidism and control subjects were evaluated and compared by calorimetric method. Also, complete urinalysis was performed in both groups. 50 patients with hyperthyroidism (mostly female and aged 26-66 years) who were confirmed by an endocrinologist were compared to an equal number of subjects in the control group (mostly female and aged 12-75 years).The collected data was analyzed by independent sample t-test.

  Results: Statistical analysis by t-test indicated that BUN concentration of serum in normal persons (14.32±3.48) and that of patients (14.89±2.49) had no significant difference(P=0.670 for men and P=0.089 for women), while creatinine concentration of serum in patients compared to normal persons showed significant differences in all sex and age groups( P=0.004 for men and P=0.0001 for women).

  Conclusion: According to the obtained results, this study indicates that in hyperthyroidism because of an increase in heart output and consequently an increase in GFR and also muscular atrophy , the serum creatinine concentrations have increased significantly but serum BUN concentrations show no significant difference in both groups. Besides, hyperthyroidism has no influence on urine analysis test.