Volume 11, Issue 44 (3-2005)                   RJMS 2005, 11(44): 1035-1041 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mehdizadeh M, Molaee F, Nobakht M, Parivar K, Mohammadzadeh F. The Effect of Cadmium Chloride on Kidney Glomeruli of Rat Embryo and Neonate. RJMS 2005; 11 (44) :1035-1041
URL: http://rjms.iums.ac.ir/article-1-107-en.html
Abstract:   (8457 Views)
Cadmium(Cd) is an environmental contaminant and an important toxic chemical with teratogenic and embryotoxic effect. Chronic human exposure to Cd will result in kidney injury. The present investigation was conducted to study the effects of cadmium chloride(CdCl2) on structural changes in rat embryo and neonate glomeruli. Thirty female Sprauge-dawley rats with mean weight of 180-240 gr were used in this study. They were classified into 6 quintet groups. On the 9th day of pregnancy, 2mg/kg Cadmium Chloride was injected intraperitoneally in right lower quadrant of abdomen in groups I & III, 4mg/kg in groups II & IV and only 1ml/kg Normal Saline in groups V & VI. Left kidneys were removed in groups I, II & V on the 21st day of pregnancy and in groups III, IV and VI 3 days after the birth. Specimens were fixed with bouin’s solution and stained with H&E for microscopic changes examination including: glomeruli number, diameter and morphology. The results showed that prenatal exposure to CdC12 can induce significant changes in the histometry and differentiation of glomeruli. Such changes appear to be restricted to the late prenatal and early post-natal period and to occur in the absence of other overt signs of toxicity.
Full-Text [PDF 344 kb]   (4433 Downloads)    
Type of Study: Research | Subject: Histology

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC-SA 4.0 | Razi Journal of Medical Sciences

Designed & Developed by : Yektaweb