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Department of Genetics & biotechnology, School of Biological Science, Varamin-Pishva branch, Islamic Azad University, Varamin, Iran
Abstract:   (46 Views)
Background:   Prostate cancer is the most commonly diagnosed malignancy and the second leading cause of cancer deaths among men in the world. Immunotherapy is a new method, non-invasive and effective for the treatment of cancer, but its side effects is on the normal flora of bacteria and opportunistic infections not known yet. The aim of this study was to evaluate of the effects of immunotherapy on Enterococcus faecalis virulence gene expression from patients with prostate cancer.
Methods: In this study, the effect of Prostate cancer immunotherapy on the expression level of esp gene which is involved in Enterococcus faecalis pathogenesis were investigated. For this purpose, the samples were analysis in three groups; normal individuals (211 men), prostate cancer patients (176 men) before and six months after Immunotherapy period.
Results:  Results showed significant (P=0.00) over expression of esp gene in prostate cancer patients after Immunotherapy. Although, there was no significant difference between prostate cancer patients before Immunotherapy and healthy subjects.
Conclusion:  We conclude from these findings that Immunotherapy could play a major role in increasing the pathogenicity risk of Enterococcus faecalis as a normal microflora. According to current Results we suggest that using antibiotic administration in the period time of Immunotherapy to prevent possible infections of opportunistic bacteria including faecalis.
Type of Study: Research | Subject: Microbiology

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