Volume 26, Issue 12 (2-2020)
RJMS 2020, 26(12): 67-77 |
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bahmani M, peeri M, azarbayjani M, delfan M. The effect of the aerobic continues and high-intensity interval training on IRE1 expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus.. RJMS 2020; 26 (12) :67-77
URL: http://rjms.iums.ac.ir/article-1-5791-en.html
URL: http://rjms.iums.ac.ir/article-1-5791-en.html
Professor of Exercise Physiology, Islamic Azad University Central Tehran Branch, Tehran, Iran. , m.peeri@iauctb.acir
Abstract: (3298 Views)
Background: The purpose of this study was to determine effect of the aerobic continuous versus high-intensity, interval training on IRE1 expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus.
Methods: Twenty-four heads of male Wistar rats (weight 160-180 g) after 7 months of high-fructose-containing diet were divided into three groups of control, aerobic continuous and intermittent exercise. They practiced the protocol in five days a week for two months. Blood samples were collected 24 h after the last training session, and liver tissue was immediately extracted. Pearson correlation, one-way ANOVA and Tukey post hoc test were used to analyze the data.
Results: Both exercise models reduced IRE1 gene expression in the liver of type 2 diabetic rats compared to the control group (P=0.005), but no significant differences were observed between the two exercise groups (P=0.877). There was a correlation between the expression of IRE1 gene and insulin resistance index such that decrease of IRE1 gene expression resulted in decrease of insulin resistance index (r=-0.667, p=0.003).
Conclusion: The results of this research show that both HIIT and continuous aerobic training can be used to improve the studied parameters in type 2 diabetic subjects.
Methods: Twenty-four heads of male Wistar rats (weight 160-180 g) after 7 months of high-fructose-containing diet were divided into three groups of control, aerobic continuous and intermittent exercise. They practiced the protocol in five days a week for two months. Blood samples were collected 24 h after the last training session, and liver tissue was immediately extracted. Pearson correlation, one-way ANOVA and Tukey post hoc test were used to analyze the data.
Results: Both exercise models reduced IRE1 gene expression in the liver of type 2 diabetic rats compared to the control group (P=0.005), but no significant differences were observed between the two exercise groups (P=0.877). There was a correlation between the expression of IRE1 gene and insulin resistance index such that decrease of IRE1 gene expression resulted in decrease of insulin resistance index (r=-0.667, p=0.003).
Conclusion: The results of this research show that both HIIT and continuous aerobic training can be used to improve the studied parameters in type 2 diabetic subjects.
Keywords: Aerobic Continuous Exercise, High-intensity interval training, Type 2 Diabetes, IRE1 Gene, Rat, Insulin resistance
Type of Study: Research |
Subject:
Exercise Physiology
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