Razi Journal of Medical Sciences

Background: The goal of the current research was investigation of effect of aerobic exercise on glucose, insulin and insulin resistance in overweight-obese subclinical hypothyroidism women.

 Methods: This study was semi-experimental. After medical screening 23 women  suffering from subclinical hypothyroidism disorder with age average of 41.08 ±6.56 years and BMI over 25 kg/m² , were objectively selected and randomly divided into two groups: control (N=13) and experimental (N=10). Initially their height, weight, BMI,, Waist-Hip Ratio (WHR) and the serum levels of fasting glucose, insulin T₄ and TSH were measured. Insulin resistance was calculated via HOMA-IR model. Then samples of experimental group  performed aerobic exercise. The control group received no intervention and were just followed. After 12 weeks all variables were measured again. For intra group comparison of data depended t-test was used and for group comparison independent t-test was used (p value ≤0.05).

Results: After 12 weeks of symphonic aerobic exercise in experimental group body composition including weight, BMI, WHR, and also insulin levels, insulin resistance and TSH had significant reduction no significant change in fasting glucose was seen and T4 levels had increased. In control group insulin and insulin resistance were significantly increased, too.

Conclusion: The reduction of cardiovascular disease and reduction of insulin resistance among over weight-obese sub clinical hypothyroidism women is probably possible through weight decreasing with aerobic exercises.