Volume 14, Issue 57 (2-2008)                   RJMS 2008, 14(57): 15-20 | Back to browse issues page

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Ehsani Pour F, Shabani, M. Determination of Lactic Dehydrogenase Level in Cerebrospinal Fluid in Neonates . RJMS 2008; 14 (57) :15-20
URL: http://rjms.iums.ac.ir/article-1-819-en.html
Abstract:   (9588 Views)

    Background & Aim: Levels of lactic dehydrogenase(LDH) in the cerebrospinal Fluid(CSF) have been used to evaluate a variety of neurologic disorders. However, few studies have been performed on neonates. The aim of this study was to detect levels of this enzyme in normal neonates. Patients and Methods: In this descriptive study, CSF samples were collected from 94 febrile infants 46 aged 0-4 weeks and 48 aged 5-8 weeks. These LDH levels were compared to those of 45 febrile infants with mean age of 10±6/2 months who were suspected of nervous system infection and normal CSF findings. Results: Mean total LDH activity in the CSF was significantly higher in the first month of life than in the second month of life as compared with the control group(p<0.001). Conclusion: We propose evaluation of total LDH activity in CSF of normal neonates according to age.

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Type of Study: Research | Subject: Pediatric Infectious

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