Volume 29, Issue 11 (1-2023)                   RJMS 2023, 29(11): 0-0 | Back to browse issues page

Research code: 24993
Ethics code: 24993
Clinical trials code: 24993

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Afravi N, Abednazari H, Helalizade M, Gholami M. The effect of HIIT and thyme extract on P53 gene expression in liver tissue and insulin resistance in type 2 diabetic rats. RJMS 2023; 29 (11)
URL: http://rjms.iums.ac.ir/article-1-7791-en.html
Assistant Professor of Exercise Physiology, Science and research branch, Islamic Azad University, Faculty of Humanities, Department physical education and sport science, Tehran, Iran , abednazari@gmail.com
Abstract:   (107 Views)
Background and purpose: Type 2 diabetes is the most common endocrine disease that occurs due to glucose intolerance due to imbalance between reserves and insulin demand. Recent research shows the vital role of p53 in the development of diabetes. The aim of this study was to study changes in p53 gene expression in liver tissue and insulin resistance index after HIIT and Zataria multiflora extract in obese type 2 diabetic rats.
Material and methods: The statistical subject consisted of wistar rats. After a 20 weeks high-fat diet by intraperitoneal injection of 25 mg STZ per kg body weight they became diabetic. Rats with fasting glucose between 150 and 400 mg / dL were considered to have type 2 diabetes. HIIT protocol and gavage performed for eight weeks, five sessions per week with 2-minute alternation of 2 and 8 intervals with 80 to 90% vo2max and a one-minute rest cycle with 50 to 56% vo2max. Thyme extract was given by gavage at a dose of 200 mg / kg 5 days a week.  
Results: Data analysis using two-way analysis of variance test showed that in comparison with the control group, HIIT led to a significant reduction in glucose and insulin resistance index. HIIT reduced P53 gene expression in hepatocytes compared with controls (P <0.009). HIIT and consumption of thyme extract also significantly reduced P53 gene expression in hepatocytes compared with the control group (P <0.05).
Conclusion: It seems that HIIT and consumption of thyme extract can help reduce liver Apoptotic factors and improve liver status in rats. As a result, researchers can use the results of this study to assess the improvement in the condition of type 2 diabetic patients
Type of Study: Research | Subject: Public Health

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