Research code: IR.IAU.PS.REC.1400.137
Ethics code: IR.IAU.PS.REC.1400.137
Clinical trials code: IR.IAU. TMB.REC. 26.199

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Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran ,
Abstract:   (102 Views)
Objectives: Nanoniosome is one of the targeted drug delivery systems that has recently attracted the attention of many researchers. The aim of this study was to investigate the encapsulation of naproxen in the nanoniosomes to investigate its antimicrobial and anti-biofilm effects.
Methods: In this experimental study, different formulations of naproxen-encapsulated nanoniosomes were synthesized. The physical and chemical properties of the synthesized nanoniosomes, including encapsulation rate, drug release rate, size and shape, were investigated using scanning electron microscopy (SEM) and Dynamic light scattering (DLS). The antimicrobial and anti-biofilm effects of the synthesized nanoniosomes were determined by the broth micro-dilution and microtiter plate methods, respectively. Finally, the expression of icaB biofilm gene was examined by Real Time PCR. The one-way ANOVA was used to analyze the data.
Results: The results showed that the optimal formulation had an average size of 125.3 nm, spherical shape and encapsulation efficiency of 66.84%. Also, the drug release results showed that the release rate of naproxen from naproxen loaded nanoniosomes and free naproxen were 68.67% and 100%, respectively, in 72 hours. Antimicrobial and anti-biofilm results showed that naproxen loaded nanoniosomes had more significant effects than the free drug. Also, nanoniosomes loaded naproxen significantly reduced the expression of icaB biofilm gene.
Conclusion: According to the results, nanoniosomes loaded naproxen have more significant antimicrobial and anti-biofilm effects than free naproxen against S. aureus strains. Therefore, in the future, with further studies, this drug delivery system can be used for antimicrobial applications. 
Type of Study: Research | Subject: Microbiology

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