Razi Journal of Medical Sciences

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In a cross-sectional study over a period of two years (Dec.2001- Dec.2003), 68 children with cerebral palsy(CP) and seizure aged 1-12 years were evaluated prospectively in Hazrat Rasoul Hospital. A control group of 60 children with seizure but no cerebral palsy at the same age group was also studied. The objective of the study was to find out the relationship between cerebral palsy and epilepsy and to determine the occurrence, associated factors, nature and prognosis of seizure in children with cerebral palsy. The mean age of seizure onset was 13±5.5 months in children with CP and 32±7.2 months in control group. In 42(61.7%) children with CP, seizure onset was during their first year of life while in control group this was only in 18(13.3%) ones. The incidence of neonatal seizure in CP children was considerably higher than that of control group (22.5% and 3.3%, respectively). 95% of children with cerebral palsy and 20% of children in control group had developmental delay. Generalized seizure was the most common type of seizure in both groups but the incidence of infantile spasm was higher in children with CP (11.7% vs. 1.6%). The incidence of status epilepticus as well as refractory seizure was higher in CP group. Furthermore, seizure control in CP children especially those with spastic tetraplegia was difficult and usually required polytherapy.

Keywords: Key Words: 1) Cerebral Palsy 2) Epilepsy 3) Status Epilepticus

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