Razi Journal of Medical Sciences

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It has been reported that chromaffin cells secrete some neuroactive substances particularly opioid peptides and catecholamines which reduce pain. Adrenal medullary implant, have been used in other injury models to provide an endogenous source of catecholamines. The goal of the present study was to determine whether adrenal medullary implants in the spinal space could repair sensory and motor function following peripheral nerve injury. For this reason 32 male Sprague Dawley rats weighing 250-300 g were allocated to 4 groups. Unilateral chronic constriction nerve injury inuced by 4 loose ligature around sciatic nerve according to Bennett and Xie model. One week after nerve surgery some animals were implanted with either adrenal medullary tissue or control tissue. Implanted tissue were obtained from adult male rats. For implantation laminectomy at L1-L2 level has been done and graft tissue was implanted under dura. Behavioral test for sensory and motor function were done prior to nerve injury (day 0) as control and 2, 4, 7, 10, 14, 21, 28, 42, 56 days after injury. Motor function was assessed using grasping and placing reflexes. Sensory behavior was determined by passive observation of animal, mechanical, paw immersion and acetone tests. Results of this study demonstrated that chronic constriction injury produce disturbance of sensory and motor function which begins after 2 days and reaches to maximum after 10 days and adrenal medullary implants into the spinal subarachnoid space can attenuate motor and sensory dysfunction in rats with peripheral neve injury.

Keywords: 1) Peripheral neuropathy 2) Chromaffin cells 3) Pain

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