Comparison of the Effect of Prostaglandin Suppository & Intravaginal Isosorbide Dinitrate on Cervical Dilatation in the First Trimester of Pregnancy

Haghighi, L; Hemmat, M

Volume 11, Issue 43 (12-2004) RJMS 2004, 11(43): 731-735 | Back to browse issues page

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Haghighi L, Hemmat M. Comparison of the Effect of Prostaglandin Suppository & Intravaginal Isosorbide Dinitrate on Cervical Dilatation in the First Trimester of Pregnancy. RJMS 2004; 11 (43) :731-735
URL: http://rjms.iums.ac.ir/article-1-67-en.html

Comparison of the Effect of Prostaglandin Suppository & Intravaginal Isosorbide Dinitrate on Cervical Dilatation in the First Trimester of Pregnancy

L Haghighi

, M Hemmat

Abstract: (118117 Views)

Abortion techniques are divided into two groups: surgical and medical. Finding drugs with least side effect and more potency is the aim of many researches in the latter technique. In recent years, prostaglandins have been one of the methods of choice in the induction of abortion. However, with recent studies on the mechanism of uteric contraction and cervical dilatation and by recognizing Nitric Oxide as an important mediator of this process, NO donors are object of many studies. With regard to few studies in this field, this research was conducted to compare the effect of intravaginal isosorbide dinitrate(an NO donor) and vaginal suppository of prostaglandin on cervical dilatation. 148 pregnant women with indication of therapeutic abortion in the first trimester were studied in two groups. The two groups were similar in terms of gestational age, parity and cervical dilatation. Cervical dilatation changes in each group during treatment were statistically significant (from 2.26±0.68cm to 4.57±1.62cm in PG and from 2.18±0.63cm to 3.63±1.11cm in ISD group). Also, the cervical dilatation difference between the two groups after treatment was statistically significant (P<0.05)(3.63±1.11cm vs 4.57±1.6cm in ISD and PG group, respectively) Furthermore, abdominal pain was more common in PG group (P<0.05). In conclusion, these two types of treatment are found to produce cervical dilatation, but the efficacy and also incidence of abdominal pain with PG is more common than ISD.

Keywords: Key Words: 1) Abortion 2) Nitric Oxide 3) Cervix

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Type of Study: Research | Subject: Gynecology