Volume 27, Issue 2 (4-2020)                   RJMS 2020, 27(2): 91-102 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

zivarpour P, zargari F. Klotho protein as a diagnostic biomarker in chronic kidney disease. RJMS 2020; 27 (2) :91-102
URL: http://rjms.iums.ac.ir/article-1-5878-en.html
Department of Medical Sciences, Marand Branch, Islamic Azad University, Marand, Iran , zargarifkb@gmail.com
Abstract:   (2379 Views)

Chronic Kidney Disease (CKD) is a worldwide public health problem with prevalence of 8 -16%. It disrupts the function and structure of the kidneys over time irreversibly, and in its advanced stages (End Stage Renal Disease-ESRD) imposes a huge financial burden on the health system of communities. Cardiovascular Disease (CVD) is one of the significant external complications, which is the most important cause of mortality in patients with CKD. Therefore, quick and early diagnosis of this disease due to its rapid and yet latent process in its earliest stages is essential to prevent side effects and avoid waste of funds. Evidence from various studies in recent years indicates that CKD progression is significantly associated with decreased levels of anti-aging protein, Klotho. Under normal physiological conditions, the major source of this protein is kidney tissue cells. Thus, Klotho deficiency is not only an early biomarker in the diagnosis of CKD, but also an important pathogenic factor in the progression and appearance of its adverse effects. This study aimed to introduce Klotho protein as an early diagnostic biomarker and to present new, effective therapeutic strategies for patients with CKD.

Full-Text [PDF 1201 kb]   (928 Downloads)    
Type of Study: review article | Subject: Biochemistry

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Razi Journal of Medical Sciences

Designed & Developed by : Yektaweb