Volume 26, Issue 7 (10-2019)
RJMS 2019, 26(7): 131-140 |
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jabbari E, Gholami M, Nikbakht H, Shakeri N, Ghazaliyan F. Effect of aerobic training and L-carnitine supplementation on some apoptotic factors in diabetic rat liver. RJMS 2019; 26 (7) :131-140
URL: http://rjms.iums.ac.ir/article-1-5798-en.html
URL: http://rjms.iums.ac.ir/article-1-5798-en.html
Assistant Professor, Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran , m.gholami@srbiau.ac.ir
Abstract: (3740 Views)
Background: The use of non-enzymatic antioxidants and proper exercise can have a positive effect on decreasing apoptotic side effect. The purpose of this study was to investigate the effect of aerobic training and consumption of l-carnitine on some of the apoptosis factors in the liver of diabetic rats.
Methods: In this experimental study, 45 male Wistar rats (200-300 gr) were randomly divided into six groups: 1) sham group, 2) healthy control group 3) diabetic control group, 4) diabetic group receiving l-carnitine, 5) diabetic group of aerobic training, 6) diabetic group of aerobic training and receiving l-carnitine. Rats were diabetic with nicotinic amide and a single dose of STZ of 55 mg / kg body weight. Rats in the L-carnitine group received daily 100 mg of l-carnitine orally. The aerobic exercise protocol done on the treadmill.
Results: Combined intervention of aerobic exercise and supplementation of l-carnitine had a significant effect on Bcl2 factor in liver tissue in diabetic rats. However, six weeks of aerobic exercise and supplementation alone do not have a significant effect, six weeks of aerobic training and combined intervention had significant effect on BAX factor in liver tissue in diabetic rats but supplementation of l-carnitine alone had no significant effect.
Conclusion: L-carnitine supplementation intake with regular exercise can have beneficial effects on apoptotic improvement in rats with type 2 diabetes
Methods: In this experimental study, 45 male Wistar rats (200-300 gr) were randomly divided into six groups: 1) sham group, 2) healthy control group 3) diabetic control group, 4) diabetic group receiving l-carnitine, 5) diabetic group of aerobic training, 6) diabetic group of aerobic training and receiving l-carnitine. Rats were diabetic with nicotinic amide and a single dose of STZ of 55 mg / kg body weight. Rats in the L-carnitine group received daily 100 mg of l-carnitine orally. The aerobic exercise protocol done on the treadmill.
Results: Combined intervention of aerobic exercise and supplementation of l-carnitine had a significant effect on Bcl2 factor in liver tissue in diabetic rats. However, six weeks of aerobic exercise and supplementation alone do not have a significant effect, six weeks of aerobic training and combined intervention had significant effect on BAX factor in liver tissue in diabetic rats but supplementation of l-carnitine alone had no significant effect.
Conclusion: L-carnitine supplementation intake with regular exercise can have beneficial effects on apoptotic improvement in rats with type 2 diabetes
Type of Study: Research |
Subject:
Physiology
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