Volume 26, Issue 7 (10-2019)
RJMS 2019, 26(7): 1-9 |
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Shahsavari R, keshavarzi F. Allelic frequency of rs2070150 polymorphism in patients with type 2 diabetes in a population of Kurdistan province. RJMS 2019; 26 (7) :1-9
URL: http://rjms.iums.ac.ir/article-1-5689-en.html
URL: http://rjms.iums.ac.ir/article-1-5689-en.html
Islamic Azad University, Sanandaj, Iran , fkeshavarzi@iausdj.ac.ir
Abstract: (2774 Views)
Background: Type 2 diabetes is a metabolic disorder. Various genetic locations play a role in susceptibility to this disease, including those in the ATF6 (Activating transcription factor. The aim of this study was to investigate the correlation between ATF6 polymorphism (rs2070150) and type 2 diabetes mellitus in patients with type 2 diabetes in Kurdistan.
Methods: The present study is a case-control study. A total of 200 blood samples 100 healthy individuals and 100 diabetic patients (age and gender matched)) from the cities of Kurdistan province were screening for ATF6 (rs2070150) polymorphism by Tetra-ARMs PCR method. The obtained data were analyzed using SPSS software and chi-square test.
Results: The results showed that 4, 12 and 84 patients, and 3, 26 and 71 healthy controls, respectively, had CC, CG and GG genotypes.
Conclusion: GC (%42) Genotype in studied population is a risk factor for type 2 diabetes (p=0.041).
Methods: The present study is a case-control study. A total of 200 blood samples 100 healthy individuals and 100 diabetic patients (age and gender matched)) from the cities of Kurdistan province were screening for ATF6 (rs2070150) polymorphism by Tetra-ARMs PCR method. The obtained data were analyzed using SPSS software and chi-square test.
Results: The results showed that 4, 12 and 84 patients, and 3, 26 and 71 healthy controls, respectively, had CC, CG and GG genotypes.
Conclusion: GC (%42) Genotype in studied population is a risk factor for type 2 diabetes (p=0.041).
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