Volume 26, Issue 5 (8-2019)
RJMS 2019, 26(5): 96-103 |
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raeisi R, zia jahromi N. Relationship between serum levels of chromium and iron with transferrin and albumin levels as carrier proteins in diabetic patients with atherosclerosis. RJMS 2019; 26 (5) :96-103
URL: http://rjms.iums.ac.ir/article-1-5614-en.html
URL: http://rjms.iums.ac.ir/article-1-5614-en.html
Shahrekord Branch Islamic Azad University, Shahrekord, Iran , nooshazia.59@gmail.com
Abstract: (3584 Views)
Background: Type 2 diabetes mellitus is one of the most common metabolic diseases in the world, resulting in complete or partial deficiency or resistance to insulin action. In this study, the association between serum levels of chromium and iron with serum levels of their carriers, transferrin and albumin in diabetic patients with atherosclerosis was investigated.
Methods: In this study, 5 cc blood samples was taken from 30 diabetic patients with atherosclerosis and 30 healthy subjects. Serum chromium and iron levels of serum were measured by atomic absorption method and spectrophotometric method, respectively. Finally, the data were analyzed using SPSS (version 23).
Results: The results showed that serum albumin level in patients was slightly increased compared to healthy subjects, but there was a significant difference (p=0.444). In the patient group, the correlation coefficient of iron and transferrin (R2=0.022) was higher than the correlation coefficient of iron and albumin (R²=0.0053) and statistically significant (p=0.05).
Conclusion: It can be concluded that in diabetic patients suffering from atherosclerosis, iron and albumin levels were higher than chromium and transferrin, but further research is needed. We hope that by studying these factors and proteins, this treatment gets more appropriate than other treatments for diabetic patients with atherosclerosis.
Methods: In this study, 5 cc blood samples was taken from 30 diabetic patients with atherosclerosis and 30 healthy subjects. Serum chromium and iron levels of serum were measured by atomic absorption method and spectrophotometric method, respectively. Finally, the data were analyzed using SPSS (version 23).
Results: The results showed that serum albumin level in patients was slightly increased compared to healthy subjects, but there was a significant difference (p=0.444). In the patient group, the correlation coefficient of iron and transferrin (R2=0.022) was higher than the correlation coefficient of iron and albumin (R²=0.0053) and statistically significant (p=0.05).
Conclusion: It can be concluded that in diabetic patients suffering from atherosclerosis, iron and albumin levels were higher than chromium and transferrin, but further research is needed. We hope that by studying these factors and proteins, this treatment gets more appropriate than other treatments for diabetic patients with atherosclerosis.
References
2. 1. Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes: Estimates for the Year 2000 and Projections for 2030. Diabetes Care; 2004. 27(5): 1047-1053.
3. 2. Friedman EA. Advanced glycosylated end products and hyperglycemia in the pathogenesis of diabeticcomplications. Diabetes Care; 1999. 22: 65.
4. 3. Marjani A. Plasma lipid peroxidation zinc and erythrocyte Cu-Zn superoxide dismutaseenzyme activity in patients with type 2 diabetes mellitus in. Gorgan City (South east of the Caspian Sea). J Med Sci; 2007. 7(4): 585-590.
5. 4. Afkhami Ardakani M. Evaluation of garlic on HbA1C in diabetic patient. J Yazd Univ Med Sci; 2002. 10: 15. [Persian]
6. 5. Parsaian N, Jalali B. Evaluation of serum Cr in diabetic patient. J Yazd Univ Med Sci; 2001. 4: 66. [Persian]
7. 6. American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care; 2004. 27(1): 5-10.
8. 7. SHIVA Atena, MABOUDI Avideh, ARAB Shahin. A review of the complications and oral manifestation of diabetes mellitus. ClinExc; 2016. 5(2): 17-27.
9. 8. Wolff Simon P, Rogert D. Glucose
10. antioxidation & protein modification: the potential role of antioxidation in diabetes. Biochem J; 1987. 454: 243-250.
11. 9. Cryer PE. Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care; 2007. 30: 190-192.
12. 10. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care; 1998. 21(9): 1414-1431.
13. 11. Kelishadi R, Ardalan G, Gheiratmand R, Adeli K, Delavari A, Majdzadeh R. The Caspian Study Group, Paediatric Metabolic Syndrome and Associated Anthropometric Indices: the CASPIAN Study. Acta Paediatr; 2006. 95: 1625– 1634.
14. 12. Meusel LAC, Kansal N, Tchistiakova E, Yuen W, MacIntosh BJ, Greenwood CE, et al. A systematic review of type 2 diabetes mellitus and hypertension in imaging studies of cognitive aging: time to establish new norms. Frontiers Aging Neurosci; 2014. 8: 6-148.
15. 13. Beckman, Joshua A, Creager. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. Jama 2002. 287(19): 2570-2581.
16. 14. Cefalu WT, Hu FB. Role of chromium in human health and in diabetes. Diabetes Care; 2004. 27(11): 2741-51.
17. 15. Nourmohammadi I, Kocheki-Shalmani I, Shaabani M, Gohari L, Nazari H. Zinc, Copper, Chromium, Manganese and Magnesium levels in serum and hair of Insulindependents diabetics. Arch Iran Med; 2000. 3: 1-5. [Farsi]
18. 16. Afridi HI, Kazi TG, Kazi N, Baig JA, Jamali MK, Arain MB, et al. Status of essential trace metals in biological samples of diabetic mother and their neonates. Arch Gynecol Obstet; 2009. 280(3):415-23.
19. 17. ParSian N, Jalai B, Afkhami Ardakani M, Ahmadiah MH. Evaluation of serem leval Chromium in diabetes patients reffering to Shahid Sadoughi debetes center Yazd. J Shahid Sadoughi Med Uni; 2002;Suppl 4: S 66-71. [Persian]
20. 18. Khosravi-Borujeni H, Amini M, Haghighi S, Ghodsi D, Khosravi A. Comparison of Iron intake in patients with impaired glucose tolerance test and healthy individuals in grade one diabetic patients. J Adv Med Biomed Res; 2006. 14(57): 39-44.
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