Volume 26, Issue 5 (8-2019)
RJMS 2019, 26(5): 87-95 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
nazari T, gaeini A A, nori R, haghshenas R. Effect of 12-week pilates training on plasma levels of PGC1-α and Irisin in obese women. RJMS 2019; 26 (5) :87-95
URL: http://rjms.iums.ac.ir/article-1-5595-en.html
URL: http://rjms.iums.ac.ir/article-1-5595-en.html
University of Tehran, Tehran, Iran , aagaeini@ut.ac.ir
Abstract: (3638 Views)
Background: Obesity is the most common metabolic disorder and important problem of the last decade. Exercise activity can reduce the negative effects of obesity by affecting PGC-1α and subsequent increases in Irisin, it can change the white adipose tissue and convert it into brown adipose tissue. The purpose of this study was to investigate the effect of 12 weeks Pilates training on the plasma values of PGC-1α and Irisin in obese women.
Methods: the research method was semi-experimental with pre-test, post-test. The statistical population was all obesity women with BMI higher than 30 and age range 25-35 in Semnan. 30 people were selected as available statistical sample from this population and were randomly assigned into two groups: experimental group and control group. The experimental group performed Pilates training protocol, which included stretching tensile exercises, neuromuscular coordination and balance, for 12 weeks, three sessions per week, and every session of 1.5 hours. The ELISA method was used to measure PGC-1α and Irisin variables 48 h before the start of the exercise protocol and 48 hours after the last exercise session. To analyze the data, covariance analysis was used at the significant level (p≤0.05).
Results: The results showed that 12 weeks Pilates training can lead to a significant increase in PGC-1α (p=0.027) and Irisin (p=0.001) in the experimental group compared to the control group.
Conclusion: The results show that 12 weeks Pilates training can lead to increase PGC-1α and plasma Irisin and it can be stated that this type of training has a positive effect on converting white adipose tissue into brown adipose tissue and increasing exothermicity in the body.
Methods: the research method was semi-experimental with pre-test, post-test. The statistical population was all obesity women with BMI higher than 30 and age range 25-35 in Semnan. 30 people were selected as available statistical sample from this population and were randomly assigned into two groups: experimental group and control group. The experimental group performed Pilates training protocol, which included stretching tensile exercises, neuromuscular coordination and balance, for 12 weeks, three sessions per week, and every session of 1.5 hours. The ELISA method was used to measure PGC-1α and Irisin variables 48 h before the start of the exercise protocol and 48 hours after the last exercise session. To analyze the data, covariance analysis was used at the significant level (p≤0.05).
Results: The results showed that 12 weeks Pilates training can lead to a significant increase in PGC-1α (p=0.027) and Irisin (p=0.001) in the experimental group compared to the control group.
Conclusion: The results show that 12 weeks Pilates training can lead to increase PGC-1α and plasma Irisin and it can be stated that this type of training has a positive effect on converting white adipose tissue into brown adipose tissue and increasing exothermicity in the body.
Type of Study: Research |
Subject:
Exercise Physiology
References
1. References
2. 1. Chiadi EN, Kunihiro M, Mariana L, Natalie B, Roger SB, Gary G, et al. Obesity and Subtypes of Incident Cardiovascular Disease. J Am Heart Assoc; 2016. 1-10.
3. 2. Handschin C, Spiegelman BM. The role of exercise and PGC1α in inflammation and chronic disease. Nature; 2008. 454(7203): 463-9.
4. 3. Kim SH, Plutzky J. Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders. Diabetes Metab J; 2016. 40(1): 12-21.
5. 4. Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1- α dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature; 2012. 481(7382): 463-8.
6. 5. Hejazi K, Attarzadeh Hosseini SR, Fathi M, Mosaferi Ziaaldini M. The Effect of Physical Activity on Adipose Tissue and Skeletal Muscles: A Literature Review. Rep Health Care; 2019. 5(1): 54-62.
7. 6. Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT. Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci; 2009. 106(48): 20405-10.
8. 7. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell; 1999. 98(1): 115-24.
9. 8. Tiraby C, Tavernier G, Lefort C, Larrouy D, Bouillaud F, Ricquier D, Langin D. Acquirement of brown fat cell features by human white adipocytes. J Biol Chemi; 2003. 278(35): 33370-6.
10. 9. Lira VA, Benton CR, Yan Z, Bonen A. PGC-1α regulation by exercise traininig and its influences on muscel function and insulin sensitivity. Am J Physiol Endocrinol Metab; 2010. 299(2): 145-161.
11. 10. Miyamoto-Mikami E, Sato K, Kurihara T, Hasegawa N, Fujie S, Fujita S, Iemitsu M. Endurance Training-Induced Increase in Circulating Irisin Levels Is Associated with Reduction of Abdominal Visceral Fat in Middle-Aged and Older Adults. PloS one; 2015. 10(3): 1-12.
12. 11. Kim HJ, Lee HJ, So B. Effect of aerobic training and resistance training on circulating irisin level and their association with change of body composition in overweight/obese adults: a pilot study. Physiol Res; 2016. 65(2): 271–279.
13. 12. Kurdiova T, Balaz M, Vician M, Maderova D, Vlcek M, Valkovic L, et al.Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: In vivo and in vitro studies. J Physiol; 2014. 592(5): 1091-107.
14. 13. Tsuchiya Y, Ando D, Goto K, Kiuchi M, Yamakita M, Koyama K. High-Intensity Exercise Causes Greater Irisin Response Compared with Low-Intensity Exercise under Similar Energy Consumption. Tohoku J Exp Med; 2014. 233(2): 135-40.
15. 14. Khodadadi H, Rajabi H, Attarzadeh SR, Abbasian S. The Effect of High Intensity Interval Training (HIIT) and Pilates on Levels of Irisin and Insulin Resistance in Overweight Women. J Diabetes Metab Disord; 2014. 16(3): 190-196. (Persian).
16. 15. Peterson J. Teaching Pilates for postural faults,
17. illness and injury: A practical guide, 1e. Philadelphia: Butterworth Hernemann Elsevier; 2009.
18. 16. Keane S. Pilates for Core Strength. United Kingdom: Greenwich Pub; 2005.
19. 17. Soltani M, Rashidlamir A, Fathi M, Ghahremanimoghaddam M. The Effect of Eight Weeks of Water Training on Sirt1, Pgc-1α and Body Fat Percentage in Obese Men. J Babol Univ Med Sci; 2018. 20(9): 55-60 (Persian).
20. 18. Lecker SH1, Zavin A, Cao P, Arena R, Allsup K, Daniels KM, Joseph J, et al. Expression of the irisin precursor fndc5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure. Circ Heart Fail; 2012. 5: 812-8.
21. 19. Jäger S, Handschin C, Pierre JS, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proc Natl Acad Sci U S A; 2007. 104(29): 12017-22.
22. 20. Novelle MG, Contreras C, Romero-Picó A, López M, Diéguez C. Irisin, two years later. Int J Endocrinol; 2013: 1-8.
23. 21. Wende AR, Schaeffer PJ, Parker GJ, Zechner C, Han DH, Chen MM, Hancock CR, Lehman JJ, Huss JM, McClain DA, Holloszy JO. A role for the transcriptional coactivator PGC-1α in muscle refueling. J Biol Chemi; 2007. 282(50): 36642-51.
24. 22. Ikeda S, Kawamoto H, Kasaoka K, Hitomi Y, Kizaki T, Sankai Y, Ohno H, Haga S, Takemasa T. Muscle type-specific response of PGC-1 alpha and oxidative enzymes during voluntary wheel running in mouse skeletal muscle. Acta Physiol (Oxf); 2006. 188: 217–223
25. 23. Heidari Sharif abadi B, Taghian F. The impact of intensity itterval training and supplementation of green tea on serum levels of irisin. Insulin resistance in obese woman with type 2 diabetes woman. J Diabetes Metab Disord; 2018. 17(6): 307-16. (Persian).
26. 24. Pekkala S, Wiklund PK, Hulmi JJ, Ahtiainen JP, Horttanainen M, Pollanen E, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health. J Physiol. 2013; 591(21): 5393-400.
27. 25. Scharhag-Rosenberger F, Morsch A, Wegmann M, Ruppenthal S, Kaestner L, Meyer T, et al. Irisin does not mediate resistance training-induced alterations in RMR. Med Sci Sports Exerc; 2014. 46(9): 1736-1743.
28. 26. Aydin S, Aydin S, Kuloglu T, Yilmaz M, Kalayci M, Sahin İ, et al. Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45min of a Turkish bath or running. Peptides; 2013. 50: 8-13.
29. 27. Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp B F. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity–correlation with body mass index. Peptides; 2013. 39: 125-30.
30. 28. Timmons J A, Baar K, Davidsen P K, Atherton P J. Is irisin a human exercise gene? Nature; 2012; 488(7413): 9-10.
31. 29. Hammonds TL, Gathright EC, Goldstein CM, Penn MS, Hughes JW. Effects of exercise on C-reactive protein in healthy patients and in patients with heart disease: A meta-analysis. Heart Lung; 2016. 45(3): 273-82.
32. 30. Fedewa MV, Hathaway ED, Ward-Ritacco CL. Effect of exercise training on C-reactive protein: A systematic review and meta-analysis of randomised and non-randomised controlled trials. Br J Sports Med; 2016. 66(5): 286-92.
33. 31. Reisi J, Ghaedi K, Rajabi H, Marandi SM. Can resistance exercise alter irisin levels and expression profiles of FNDC5 and UCP1 in rats? Asian J Sport Med; 2016. 7(4): 1-6.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
