Volume 26, Issue 3 (5-2019)
RJMS 2019, 26(3): 59-66 |
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hojatoleslami L, Tadibi V, behpoor N. The effect of eight weeks of resistance training on nitric oxide and apelin levels in women with pre-hypertension. RJMS 2019; 26 (3) :59-66
URL: http://rjms.iums.ac.ir/article-1-5473-en.html
URL: http://rjms.iums.ac.ir/article-1-5473-en.html
Exercise Physiology Department, Faculty of Sport Sciences, Razi University, Kermanshah, Iran , vahidtadibi@razi.ac.ir
Abstract: (2871 Views)
Background: High blood pressure is a threat to the health of individuals, especially women. In order to overcome this threat, the purpose of this study was to investigate the effect of eight weeks of resistance training on blood pressure and Nitric oxide and Apelin levels in women with pre-hypertension.
Methods: For this purpose, 24 women with pre-hypertension aged from 30 to 45 years old were randomly divided into two groups of exercise and control. The training group performed three resistance training sessions per week for eight weeks. One day before and 48 hours after the last session of the training, blood sampling was taken from the subjects. The changes of Apelin and Nitric oxide levels were measured by Elisa method. Paired t-test and independent t-test were used for within and between groups comparisons, respectively (p<0.05).
Results: The results showed that Apelin and Nitric oxide levels increased significantly (p <0.001) and systolic and diastolic blood pressure decreased significantly (p <0.001) in the training group. However, no significant changes were observed in the control group.
Conclusion: Performing an eight-week moderate-intensity resistance training program can reduce the levels of blood pressure, apelin, and Nitric oxide in women with pre-hypertension.
Methods: For this purpose, 24 women with pre-hypertension aged from 30 to 45 years old were randomly divided into two groups of exercise and control. The training group performed three resistance training sessions per week for eight weeks. One day before and 48 hours after the last session of the training, blood sampling was taken from the subjects. The changes of Apelin and Nitric oxide levels were measured by Elisa method. Paired t-test and independent t-test were used for within and between groups comparisons, respectively (p<0.05).
Results: The results showed that Apelin and Nitric oxide levels increased significantly (p <0.001) and systolic and diastolic blood pressure decreased significantly (p <0.001) in the training group. However, no significant changes were observed in the control group.
Conclusion: Performing an eight-week moderate-intensity resistance training program can reduce the levels of blood pressure, apelin, and Nitric oxide in women with pre-hypertension.
Type of Study: Research |
Subject:
Exercise Physiology
References
2. 1. Ahmadi A, Hasanzadeh J, Rajaeifard A. The study of factors affecting hypertension in Koohrang city. Iran J Epidemiol; 2008.4(2):19-25. (Persian).
3. 2. Collier S. Sex Differences in the Effects of Aerobic and Anaerobic Exercise on Blood Pressure and Arterial Stiffness. Gend Med; 2008:115-23.
4. 3. Denise L, Smith B, Fernhall U. Advance cardiovascular exercise physiology: Human Kinetics; 2011. 91-210.
5. 4. Tatemoto K, Takayama K, Zou M. The Novel Peptide Apelin Lowers Blood Pressure Via a Nitric Oxide-Dependent Mechanism. Regul Pept; 2001.99(2-3):87-92.
6. 5. Dean N, Shuaib A. Hypertension: the most important preventable risk factor for cerebrovascular disease. Lancet Neurol; 2011.10(7):606 -7.
7. 6. Heinonen M, Purhonen A, Miettinen P. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Regul Pept. 2005;130(1-2):7-13.
8. 7. Kalea A, Batlle D. Apelin and ACE2 in cardiovascular disease. Curr Opin Investig Drugs. 2010;11(3):273-82.
9. 8. Boucher J, Masri B, Daviaud D, Gesta S, Guigné C, Mazzucotelli A. Apelin, a newly identified adipokine up regulated by insulin and obesity. Endocrinology. 2005;146(4):1764-71.
10. 9. Kleinz M, Skepper J, Davenport A. Immunocytochemical Localisation of the Apelin Receptor, APJ, to Human Cardiomyocytes, Vascular Smooth Muscle and Endothelial Cells. Regul Pept. 2005;126(3):233-40.
11. 10. Lauglin N, Woodman W. Interval Sprint Training Enhanced Endothelial Function and eNOS in Some Arteries That Perfuse White Gasterocemius Muscle. J Appl Physiol. 2004;66(1):233-44.
12. 11. Rezk C, Marrache R, Tinucci T, Forgaz C. Post-resistance exercise hypotension, hemodynamics, and heart rate variability:influence of exercise intensity. Appl Physiol. 2006;98:105-12.
13. 12. Faraji H, Bab L, Ardeshiri H. Effects of resistance exercise intensity and volume on post exercise hypotensive responses. Braz J Biomotr. 2010;4(1):65-73.
14. 13. Hakimi M, Mohammadi A, Baqaei B, Sahkhoeyan M, Blabley L. Comparison of the effects of 12 weeks resistance and endurance training on ANP, endothelin-1, apelin and hypertension in middle-aged men with high blood pressure. Urmia Med J. 2016;26(12):1080-9. (persian).
15. 14. Mokhtari M, Daryanoush F,. The effect of 12 weeks of resistance training on plasma levels of apelin 12, nsafatin 1 and resting heart rate in elderly women with hypertension. Med J Mashhad Uni Med Sci. 2015;6:330-7. (persian).
16. 15. Teixeira T, Tibana R, Nascimento D. Endothelial nitric oxide synthase Glu 298 Asp gene polymorphism influences body composition and biochemical parameters but not the nitric oxide response to eccentric resistance exercise in elderly obese women. Clin Physiol Funct Imaging. 2016;36(6):482-9.
17. 16. Milton R, Reury F. chronic conventional resistance exercise reduces bloodpressure in stage 1 hypertensive men. J Strength Cond Res. 2011:1–8.
18. 17. Ebrahimi H, Ahmadizad s, Homayi H, Javidi M. Blood pressure and heart rate response to resistance protocols and movements. Ebnesina. 2016;17(4):43-51. (persian).
19. 18. Mogharnasi M, Bagheri M. Effect of 12 weeks of circuit resistance training on C-reactive protein and lipid profiles in inactive women. Sport Biosci. 2014;6(2):233-244. (persian).
20. 19. Swain, David P. ACSM's guidelines for exercise testing and prescription. Wilkins WKHLW, editor. American College of Sports Medicine 2014 7th ed. 693 p.
21. 20. QardashiEfusi A, Gaeni A, GholamiBroujeni B. The Effect of Aerobic Exercise on Plasma Levels of Nitric Oxide, Vascular Endothelial Cell Function and Secondary Outcome in Patients with Type 2 Diabetes. J Nurs Rehab. 2016;2(3):27-39. (persian).
22. 21. Macedo FN, Mesquita TR, Melo VU, Mota MM, Silva TL, Santana MN et al. Increased Nitric Oxide Bioavailability and Decreased Sympathetic Modulation Are Involved in Vascular Adjustments Induced by Low-Intensity Resistance Training. Front Physiol. 2016. 28(7):265. (Abstract)
23. 22. Shekarchizadeh K, Khazaei M, Garakhanlo R, Karimian G, Safarzadeh A. The effect of resistance training on plasma levels of nitric oxide, vascular endothelial growth factor and its type 1 receptor in healthy male rats. J Isfahan Med School. 2013;30(176). (persian).
24. 23. Zaros P, Romero P, Bacci M, Moraes C, Zanesco A. Effect of 6- months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women. BMC J Women Health. 2009;17(2):142-50.
25. 24. Siasos S, Athanasiou D, Tousoulis D, Terzis G, Stasinnaki A, Tourikis P. Acute effects of different types of aerobic exercise on vascular function. J Am Coll Cardiol. 2014;63(12):16-42.
26. 25. Wallace J. Exercise in hypertension. Sports Med. 2003;33(8):1-15.
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