Volume 26, Issue 5 (8-2019)                   RJMS 2019, 26(5): 56-66 | Back to browse issues page

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Abdollahpour A, Rajabi H, Gaeini A, Sofi-abadi M, Khaledi N. The effect of aerobic exercise during pregnancy on vascular BCL-2, BAX and eNOS gene expression in adult male offspring rat. RJMS 2019; 26 (5) :56-66
URL: http://rjms.iums.ac.ir/article-1-5430-en.html
Kharazmi University, Tehran, Iran , hrajabi@khu.ac.ir
Abstract:   (3711 Views)
Background: Change in vascular function is considered to be an indicator for vascular disease. Effective factors on vascular function are enzyme eNOS and apoptotic regulator factors including BCL-2 and BAX. The purpose of this study was to investigate the effect of aerobic exercise during pregnancy on vascular gene expression of BCL-2, BAX, and eNOS in Sprague dawley rats offspring
Methods: Ten 8-week-old females Sprague Dawley rats were randomly divided into two groups of exercise during pregnancy (T) (221±9.9) and sedentary (C) (223.8±8). The aerobic exercise training was performed immediately after observation of the vaginal plaque for 21 days and 5 sessions per week with moderate intensity (35-45% vo2 max). About 2 days before delivery, their training program was terminated. Femoral artery samples were collected at 8 weeks of male offspring age. Data was analyzed with independent t-test for between group comparisons. The level of significance was set at p<0.05. Statistical analyses were carried out using the SPSS software (version 16).
Results: The results of the study showed that 21 days of aerobic exercise training with moderate intensity during pregnancy increased significantly mRNA of the BCL-2 gene(P=0.004), decreased significantly mRNA of the BAX gene in male offspring (p=0.000), but there was no significant change in mRNA of the eNOS gene (p=0.494).
Conclusion: It seems that moderate aerobic exercise during pregnancy can reduce apoptosis as a result of vascular dysfunction in adult offspring.
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Type of Study: Research | Subject: Exercise Physiology

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