Volume 25, Issue 10 (1-2019)
RJMS 2019, 25(10): 38-45 |
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Hemati K, Mehrzadi S, Bakhtiarian A, Motevalian M, Nikouei V, Foroohandeh M, et al . Miswak sticks’ extract anti-inflammatory properties in carrageenan test. RJMS 2019; 25 (10) :38-45
URL: http://rjms.iums.ac.ir/article-1-5368-en.html
URL: http://rjms.iums.ac.ir/article-1-5368-en.html
Karim Hemati 
, Saeed Mehrzadi , Azam Bakhtiarian , Manijeh Motevalian , Vida Nikouei , Mehrdad Foroohandeh , Mohammad Yahya Karimi , Vahid Nikoui
, Saeed Mehrzadi , Azam Bakhtiarian , Manijeh Motevalian , Vida Nikouei , Mehrdad Foroohandeh , Mohammad Yahya Karimi , Vahid Nikoui
Iran University of Medical Sciences, Tehran, Iran , nikoui.v@iums.ac.ir
Abstract: (3315 Views)
Background: Miswak is the product of Salvadora persica L. that has antibacterial, antifungal, antiplasmudium, anticonvulsant, and gastroprotective properties. In this study, the anti-inflammatory effect of aqueous extract of miswak sticks (Salvadora persica L.) was investigated in carrageenan-induced rat paw edema.
Methods: Adult male rats were divided into five groups, receiving normal saline, indomethacin (5 mg/kg), extract of Salvadora persica L. (50, 75, and 100 mg/kg), intraperitoneally. Then, carrageenan was injected into plantar surface of paw, and edema was measured using a micrometer in different times.
Results: Salvadora persica L. extract at dose of 50 mg/kg reduced inflammation at 4 and 5 hours after carrageenan injection (p<0.05). Doses of 75 mg/kg (p<0.01) and 100 mg/kg (p<0.001) of this extract exerted anti-inflammatory effects at 4, 5, and 6 hours after carrageenan injection. Indomethacin also decreased edema, significantly compared to saline-injected group (p<0.0001).
Conclusion: Our data revealed that Salvadora persica L. extract possesses anti-inflammatory properties. However, further experiments on the possible use of this plant in inflammatory disorders are required.
Methods: Adult male rats were divided into five groups, receiving normal saline, indomethacin (5 mg/kg), extract of Salvadora persica L. (50, 75, and 100 mg/kg), intraperitoneally. Then, carrageenan was injected into plantar surface of paw, and edema was measured using a micrometer in different times.
Results: Salvadora persica L. extract at dose of 50 mg/kg reduced inflammation at 4 and 5 hours after carrageenan injection (p<0.05). Doses of 75 mg/kg (p<0.01) and 100 mg/kg (p<0.001) of this extract exerted anti-inflammatory effects at 4, 5, and 6 hours after carrageenan injection. Indomethacin also decreased edema, significantly compared to saline-injected group (p<0.0001).
Conclusion: Our data revealed that Salvadora persica L. extract possesses anti-inflammatory properties. However, further experiments on the possible use of this plant in inflammatory disorders are required.
Type of Study: Research |
Subject:
Pharmacology
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