Volume 26, Issue 7 (10-2019)                   RJMS 2019, 26(7): 24-32 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Taherkhani B, Mirazi N. Study of Vitis vinifera L. seed's hydroethanolic extract on blood parameters in male rats induced with cyclophosphamide. RJMS 2019; 26 (7) :24-32
URL: http://rjms.iums.ac.ir/article-1-5328-en.html
Professor, Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina UniversityBu-Ali Sina University, Hamedan, Iran , mirazi205@gmail.com
Abstract:   (2819 Views)
Background: Cyclofosfamide has damage effect on bone marrow and changes blood parameters. The seed of Vitis vinifera L. has anti-oxidants, anti-inflammatory and anti-bacterial effects. The aim of this study is to investigate the Vitis vinifera' seed extract (VSE) on blood parameters in male rat treated by cyclofosfamide.
Methods and Material: 42 adult male Wistar rats (220±20 gr) were devided into 6 groups (n=7) randomly. The control group (0.5 ml normal saline- daily, i.p), witness group (15 mg/kg cyclophosphamide, i.p), positive control group (200mg/kg VSE, i.p), treated groups1,2 & 3 (100 mg/kg, 200 mg/kg & 400 mg/kg VSE + 15 mg/kg cyclophosphamide daily, i.p, for 10 days). At the end of examinations, the animals were anesthetized with ethyl ether and blood samples were collected from heart directly. The blood parameters such as RBC, WBC, PL, HB and Hct were analysed.
Results: The blood cells and platelets were decreased in witness group comparing with control group significantly (p<0.001). The RBC, WBC, PL and hemoglobin significantly increased in positive control group compare to cyclophosphamide treated group (p<0.001). In treated groups with cyclophosphamide + VSE the blood cells and PL increased significantly compared with witness group (p<0.01).
Conclusion: The use of VSE has protective effects on blood parameters in rats induced with cyclophosphamide.
Full-Text [PDF 1294 kb]   (1410 Downloads)    
Type of Study: Research | Subject: Physiology

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Razi Journal of Medical Sciences

Designed & Developed by : Yektaweb