Volume 12, Issue 48 (9-2005)                   RJMS 2005, 12(48): 27-34 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Entezami K, Shah Ghasempour S, Rakhshan M, Nikrah E. Expression of MHC Class I and ICAM-I Association between Breast Cancer and Hyperplasia Biopsy Specimen in Women Aged between 35-65 Years by Indirect Immunofluorescence. RJMS 2005; 12 (48) :27-34
URL: http://rjms.iums.ac.ir/article-1-507-en.html
Abstract:   (8370 Views)
    Background & Aim: Major histocompatibility complex(MHC) class one and intercellular adhesion molecule-I(ICAM-I) play important roles in immune response. It is well known that the expression level of the MHC class I and ICAM-I is frequently altered in accordance with tumor progression and is significantly related to tumorigenesis, tumor progression, and/or metastatic potential(e.g.kidney and prostate cancers). The aim of this study was based on the hypothesis that decreased or absent expression of MHC class I and ICAM-I surface antigens or costimulatory molecules on tumor cells might be responsible, in part, for the progression of breast cancer. Patients & Methods: To investigate the expression level of above molecules, 25 breast cancer and 25 breast hyperplasia cells samples from women aged between 35-65 years were obtained. Then, biopsy specimens from samples were prepared. Indirect immunofluorescence technique and H&E staining were used. Results: Immunohistochemical and pathological analysis in this study revealed a negative correlation between the expression of MHC-I and ICAM-I surface antigens and grade (differentiation) of breast cancer was compared with breast benign hyperplasia cell samples. Results were expressed as the mean±SD. Student’s t-test and SPSS program were used to assess the differences, and a significant level of P<0.00 was found. Conclusion: In general, tumor with higher grade(cell differentiation) expressed MHC class I and ICAM-I sufrace antigens on breast cancer cell less frequently and intensely. The absence or decreased level of MHC and ICAM-I surface antigen expression on women breast cancer cells is responsible for tumor progression.
Full-Text [PDF 1171 kb]   (2981 Downloads)    
Type of Study: Research | Subject: Immunology

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Razi Journal of Medical Sciences

Designed & Developed by : Yektaweb