Volume 25, Issue 1 (3-2018)
RJMS 2018, 25(1): 58-66 |
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Ahmadi R, Sagharjoghi Farahani M, Khodadadi B. The effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in vitro. RJMS 2018; 25 (1) :58-66
URL: http://rjms.iums.ac.ir/article-1-4975-en.html
URL: http://rjms.iums.ac.ir/article-1-4975-en.html
Islamic Azad University, Islamshahr, Iran , m.farahni@iaups.ac.ir
Abstract: (3950 Views)
Background: Studies showed thyroid hormones influence proliferation of cancer cells. The main aim of this study was to investigate the effects of cytotoxic thyroid hormone T4 on proliferation of brain glioblastoma cells (A172) in cell culture.
Methods: In this laboratory experimental study, A172 cells were randomly divided into control group and groups exposed to doses 0.1, 0.5, 1, 5, 10, 20, 40, 50 Lambda (λ) of thyroid hormone T4. The toxic effect of hormones was measured using MTT assay method. The data were statistically analyzed between groups using ANOVA.
Results: The result demonstrated that highest toxicity of thyroid hormone T4 on glioblastoma cancer cells A172 was in 1 lambda (λ) dosage and low toxicity in 0.1 and 40 lambdas (λ) dosages.
Conclusion: Toxicity of Glioblastoma cancer cells is either hormone dependent or hormone independent.
Methods: In this laboratory experimental study, A172 cells were randomly divided into control group and groups exposed to doses 0.1, 0.5, 1, 5, 10, 20, 40, 50 Lambda (λ) of thyroid hormone T4. The toxic effect of hormones was measured using MTT assay method. The data were statistically analyzed between groups using ANOVA.
Results: The result demonstrated that highest toxicity of thyroid hormone T4 on glioblastoma cancer cells A172 was in 1 lambda (λ) dosage and low toxicity in 0.1 and 40 lambdas (λ) dosages.
Conclusion: Toxicity of Glioblastoma cancer cells is either hormone dependent or hormone independent.
Type of Study: Research |
Subject:
Endocrinology & Metabolism
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