Volume 25, Issue 2 (4-2018)                   RJMS 2018, 25(2): 21-29 | Back to browse issues page

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Mohammadi T, Hoveizi E. Cellular and Molecular Evaluation of Cinnamon Hydroalcoholic Extract Effect on Lung Cancer Cells in Comparison with Cyclophosphamide. RJMS 2018; 25 (2) :21-29
URL: http://rjms.iums.ac.ir/article-1-4900-en.html
Shahid Chamran University of Ahvaz , t.mohammadi@scu.ac.ir
Abstract:   (4129 Views)

Background: Lung cancer is the most common cause of cancer death worldwide.  Despite extensive efforts, an ideal medicine has not been yet found for cancer treatment. Cinnamon contains strong anti-oxidative compounds. This study evaluated and compared the lethal effect of cinnamon extract on the A459 line lung cancer cells with cyclophosphamide. Methods: Cinnamon extract was prepared by soxhlet set. Then A459 cells were seeded and treated with 0.01, 0.1, 1 and 10 mg/ml concentrations of cinnamon and cyclophosphamide for 1, 3 and 5 days. Cell viability and morphology were evaluated on certain days after treatment. The expression of apoptotic genes including Bad, Bax and Bcl-2 was evaluated by qRT-PCR.
Results: Comparison of the cell viability percent in treated groups showed that lethal effect of cinnamon is equal to cyclophosphamide in 1 and 10 mg/ml concentrations on the 5th day but it was less than cyclophosphamide in other concentrations and days (p<0.05). Moreover, molecular findings showed that 1 and 10 mg/ml concentrations of cinnamon extract could up-regulate Bad and Bax genes expression and down regulate Bcl-2 gene expression (p<0.05). Conclusion: Cinnamon hydroalcoholic extract can induce apoptosis in A459 cells in a dose and time-dependent manner and be similar to cyclophosphamide with increasing concentration.

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Type of Study: Research | Subject: Biology

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