Razi Journal of Medical Sciences

Background: Blood glucose increases production of Reactive Oxygen Species (ROS) and oxidative stress in diabetic patients. Recent research suggests that use of probiotics have beneficial effects on biomarkers of oxidative stress. The aim of this study was to determine effects of probiotics Lactobacillus acidophilus and Lactobacillus casei on biomarkers oxidative stress in streptozotocin-induced diabetic rats.
Methods: 32 male wistar rats were assigned to 4 groups randomly: group CN, consumed a normal standard diet (with buffer saline 0.2), group CL (probiotic diet 10⁹cfu / ml), group D (diabetic rats+high fat diet), group DL (diabetic rats+high fat+probiotic). After 6 weeks levels of malondialdehyde, total antioxidant and antioxidant enzymes (catalase, glutathion peroxidase and superoxide dismutase) were measured.
Results: A significant decreases in serum levels of malondialdehyde and significant increase in levels of antioxidant enzymes (catalase  and glutathion peroxidase) and total antioxidant capacity were observed in the probiotic supplements groups (p<0.05).
Conclusion: Consumption of probiotics Lactobasilus acidophilus and Lactobacillus casei had beneficial effects on biomarkers of oxidative stress in diabetic rats.