Razi Journal of Medical Sciences

Background: Osteoporosis as a multifactorial disease caused by decreased bone mineral density (BMD) especially calcium increasing fracture risk. Vitamin D binding protein (VDBP or Gc) is a molecule key to the biologic actions of vitamin D. Mutation in some critical areas of VDBP can affect metabolism of minerals specially calcium that are important in bone density. This study investigated association of rs7041 and rs4588 polymorphisms of VDBP gene with osteoporosis in postmenopausal Azari women in Zanjan.

Methods: This was a case-control study. Peripheral blood samples were collected from 50 osteoporosis and 50 normal postmenopausal Azari women for DNA extraction. Genotypes of rs7041 and rs4588 polymorphisms of VDBP gene were studied by PCR-RFLP. For statistical analysis we used SPSS-14, t-test and X².

Results: We found no significant association among rs7041 and rs4588 polymorphisms and three haplotypes (Gc1s, Gc2, Gc1f) and osteoporosis (p>0.05).

Conclusion: Our results suggest that genotypes of VDBP were not associated with susceptibility to osteoporosis in postmenopausal women; however, according to similar or inconsistent results in other studies from other countries, this study should be repeated in larger population and with other ethnic groups for more reliable results.