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URL: http://rjms.iums.ac.ir/article-1-4404-en.html
, Parvin Ayremlou2 , Mir Amir Aghdashi Aghdashi3 , Seyyed Mostafa Seyyed Mardani3 , Rasoul Zarrin *4
2- Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran, Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran
3- School of Medicine, Urmia University of Medical Sciences, Urmia, Iran, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
4- Assistant Professor of Nutrition, Food and Beverages Safety Research Center, Department of Nutrition, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran, Assistant Professor of Nutrition, Food and Beverages Safety Research Center, Department of Nutrition, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran ,
Background: Lipid disorders are the considerable cause and main reason for development of cardiovascular and atherosclerotic disease in rheumatoid arthritis patients. Ginger has the anti-inflammatory and hypolipidemic effect. This study was conducted to evaluate the effect of Ginger powder on lipid profile in rheumatoid arthritis patients.
Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted on 72 rheumatoid arthritis referred to rheumatologic clinic of Urmia Emam Khomeini Hospital. Patients were divided randomly into 2 groups, intervention group (receiving ginger tablet 1.5 gr/day) and placebo group (placebo tablet 1.5 gr/day) for 8 weeks. Lipid profile before and after intervention was compared within groups using paired t-test and the mean differences using independent t-test between two groups.
Results: At the end of the intervention period, 67 (93.06%) of patients were analyzed. The study showed that in the ginger group, mean of LDL-C decreased after intervention (104.22±20.60) in comparison to before (115.19±24.86) and mean of HDL-C increased (50.21±10.16 at before and 55.27±10.19 after the intervention) significantly (p<0.001). In placebo group, mean of LDL-C (113.86±19.19 at before and 118.88±22.38 after the intervention), TG (134.09±59.70 at before and 143.97±57.21 after the intervention) and total cholesterol (190.12±26.90 at before and 199.17±32.50 after the intervention) increased significantly (p<0.05). Mean changes of LDL-C, HDL-C and total cholesterol after intervention was significant between two groups (p<0.05). Mean of TG in ginger group in comparison to placebo group increased slightly but it’s changes after was not significant between groups (p=0.36).
Conclusion: Current study showed that ginger powder compared to placebo has the ability to modify lipid profile in patients with rheumatoid arthritis.
