Razi Journal of Medical Sciences

 ABSTRACT

Changes in metabolism of lipids and lipoproteins in diabetes mellitus have been reported. These changes seen to be the cause of cardiovascular diseases. In this study, 143 patients with type two diabetes mellitus were recruited at Yazd diabetic clinic. After 12 to 14 hours fasting, blood was taken from a forearm vein and serum glucose, triglyceride, cholesterol, HDL-c, and VLDL-c were measured. 76 control nondiabetic subjectes were randomly recruited. Serum triglyceride, VLDL-c and HDL-c in patients were significantly higher and serum LDL-c was lower compared with those in normal subjects. Use of glybenclamide tablets and insuline injection reduced serum LDL-c and increased HDL-c significantly in the patients. Duration of diabetes had no effect on serum triglyceride, cholesterol, HDL-c, LDL-c and VLDL-c levels.