Razi Journal of Medical Sciences

 ABSTRACT

This study was desinged to evaluate the teratogenic effect of garthahus tinctorius (Golrang) Extract on the development of central nervous system (CNC) of suri albino variety mice. The extract was given from day 1 to 8th of preanancy with doses of 0.2, 0.8, 1.2, 1.6 and 2 mg/kg, each dose to one group of mice with 6th group serving as control. Day zero of preanancy was considered day one. On the thirteenth day fetuses were delivered by cesariah section and studied for CNS changes. Formation, changing morphology of consisting cells, inspection of lonvitudinal, internal and external diameter of various parts of neural tube and closure of neuropores, were the main indeses which were looked for. In group 1.6 and 2 mg/kg fetuses absorbed. In group 0.2 and 0.8 mg/kg some changes were observed. In 1.2 mg/kg group neural tube was not obstructed but cellular chanaes Both Qualitative and Quantitative were noted.