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URL: http://rjms.iums.ac.ir/article-1-3887-en.html
Background: Leishmaniasis is a parasitic infectious disease caused
by Leishmania spp with different clinical manifestations. After phagocytosis,
the parasite becomes resistant to anti pathogenic mechanism of macrophages.
Innate immune responses such as TNF-α have important role in enhancement of
phagocyte activities against the parasite. During a performed study on the
prevalence of leishmaniasis in Isfahan province, we found that a number of
people living in this endemic region never show the clinical leishmaniasis despite
of close exposure. While the natural resistance may contribute to some elements
in innate immune response such as TNF-α levels, the present study aimed to
investigate the effects of serum level of TNF-α in healthy people of Isfahan.
Methods: Blood samples were obtained from 50
healthy subjects living in Isfahan and 50 healthy subjects from Tehran. Of all
subjects who were referred to Iranian Blood Transfusion Organization (IBTO) written
informed consent was obtained. Blood sample separated
plasma was stored in the -70°c until tested. Plasma level of TNF-α was measured
by Sandwich ELISA (USCN, China) according to the manufacture´s protocol. Data
were analyzed using the Chi-Square and t- test through SPSS software.
Results: The analysis showed that the levels of
TNF-α in Isfahan healthy residents were significantly higher than those in
Tehran healthy subjects (p=0.085).
Conclusion: The results obtained in the present
study confirmed our previous finding indicating a natural resistance to
leishmaniasis in Isfahan residents. Accordingly we suggested that the
assessment of serum TNF-α may be useful in the prognosis and prevention of
cutaneous Leishmaniasis in the endemic regions.
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