Razi Journal of Medical Sciences

Background: The aim of this study was to determine the effect of 8 weeks endurance training and L-NAME on Apelin in myocardial tissue and glucose in elderly male’s rats. Methods: For this purpose, 24 vistar elderly rats with average 20 months old purchased from Razi Institute and transferred to Research Center were randomly divided into four groups: 1. control, 2. training, 3.training and L-NAME and 4. L-NAME. Training protocol performed for 8 weeks and 5 days a week with 75-80% VO2max. All rats were killed 72 hours after the final training session and after 24 hours of fasting myocardial tissue and plasma samples were collected and kept in -80. Also, Data was analyzed with One way ANOVA and Tucky in p<0/05. Results: Results of one-way ANOVA showed a significant difference between the groups in myocardial tissue Apelin (p <0.00). Also, the results showed no significant difference between the levels of glucose groups. Conclusion: It is likely that a combination of endurance training and the inhibitor of nitric oxide, change Apelin levels of myocardial tissue.