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URL: http://rjms.iums.ac.ir/article-1-3593-en.html
, Vahid Bayati , Reza Nejatbakhsh , Mohammad Hasan Heidari , Masoomeh Dadpay , Azadeh Tavassol
Background: More than 90% of women use drugs during pregnancy. The
aim of this study was to investigate oral morphine-induced histopathological
changes in Wistar rat fetuses’ liver.
Methods: Animals were divided to 1 control and 3 drug level
induced groups. 0.1, 0.2 and 0.3 mg/ml of morphine sulphate (99.98%) in
drinking water (25 ml) were administered orally to pregnant rats from day 8 to
20. On gestation day 21, fetuses were removed surgically and after removing
liver of fetuses, samples of tissue stained by hematoxylin and eosin (H&E)
method and studied under light microscope. The data evaluated by SPSS software,
ANOVA and analysis varieties.
Results: In the experimental groups with dose 0.1, 0.2 and 0.3
mg/ml of morphine, liver sections appeared with vacuolated hepatocytes, dilated
sinusoids, and increased number of kupffer cells, lymphocytes and neutrophils.
The results in experimental groups with doses 0.2 and 0.3mg/ml of morphine were
significant comparing with control group (p≤ 0.001).
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