Volume 21, Issue 128 (2-2015)                   RJMS 2015, 21(128): 1-7 | Back to browse issues page

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Mohammadi R, Fallahmohammadi Z, Aghajani K. Pre-treatment effects of hydroalcoholic extraction of Eriobotrya japonica on GDNF levels in the brain stem of parkinsonian rats after 6 weeks of voluntary exercise . RJMS 2015; 21 (128) :1-7
URL: http://rjms.iums.ac.ir/article-1-3552-en.html
University of Mazandaran, Babolsar, Iran
Abstract:   (5491 Views)
 

Background: We investigated the effects of 12 weeks of voluntary exercise on a running wheel with extraction of flowers Eriobotrya japonica on GDNF in the brain stem induced by 6-hydroxy dopamine.

 

Methods: In this study, 43 rats were divided into six groups: healthy control, parkinsonian control, training group, parkinsonian training, extract parkinson, training-extract parkinsonian. Training-extract group were housed in individual cages and attached to running wheels during the study period they received 200 mg/kg extract intraperitoneally three times per week. To induce Parkinson, 6-hydroxy dopamine (6-OHDA) (dissolved in saline) was administered intracerebrovenricular (ICV) by a stereotaxic apparatus. GDNF levels in the brain stem were measured by ELISA. Data was analyzed using one-way analysis of variance (ANOVA) and tukey post-hoc test.

 

Results: There are significant differences in the level of GDNF between training group and parkinsonian control (p=0.015) between parkinsonian training group and parkinsonian control group there was significant difference (p=0.015). GDNF level between training group and parkinsonian training with parkinsonian control was not significant (0. 87, 0.095). There was significant difference between control and parkinsonian control group (p=0.004). Difference between extract-parkinson group and parkinsonian control was not significant (p=0.191). GDNF level difference between extract-training and parkinsonian control was significant (p=0.008). Brainstem GDNF level in extract-parkinson and parkinsonian control (p=0.191) and extract-parkinson and control (P=0.164) was not significant.

 

Conclusion: Pre-treatment with exercise alone and exercise with extraction of Eriobotrya japonica could prevent the decrease of GDNF level in brainstem against neurotoxic 6-OHDA.

 

 

 
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Type of Study: Research | Subject: Exercise Physiology

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