Razi Journal of Medical Sciences

 Recently the Combined Therapy of omeprazole (O) a powerful anti ulcer drag with antibiotic has been studied in patients with helicobacter pyloi (HP) associated duodenal ulcer (DU). The efficacy of (O) plus ciprofloxacin (C) Therapy on healing of Du and eradication of HP was tested in a randomized, double-blind, placebo controlled prospective study. Eighty four patients with HP positive Du disease were randomly assigned to receive O 20 mg (28 days) plus C 250 mg bid (7 days) or placebo. The patients were devided in to following four groups.

 Group 1 (O+C n=22)

 Group 2 (O placebo +C placebo n=22)

 Group 3 (O placebo +C n=19)

 Group 4 (O+C placebo n=21)

  Endoscopy and two biopsies from antrum for rapid urease test and histology were performed in all patients at the entry and three to seven days after the end of the therapy.

  Du healing rates were 88% in group 1, 13% in group 2, 24% in group 3, and 78% in group 4, the proportions of Hp negativity were 65% in group 1, 13% in group 2, 19% in group 3, and 24% in group 4. The highest rates of ulcer healing or Hp eradication were observed in group 1 receiving O+C.

  1- Omeprazole is a safe and effective drug for short termulcer therapy in patients with Du disease.

  2- Omeprazole plus ciprofloxacin therapy is highly effective concerning Hp eradication.

  3- Du healing rate with o plus c Therapy may be increased as compared to omeprazole therapy olane.