Razi Journal of Medical Sciences

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fallah A, gharakhanlou R, soleimani M, mojtahedi S. The expression of miR-206 in response to one session resistance exercise in fast and slow twitch skeletal muscles of Wistar male rats. RJMS 2016; 22 (139) :56-63
URL: http://rjms.iums.ac.ir/article-1-3466-en.html

Background: MicroRNAs are non-coding RNAs that are involved in post-transcriptional down regulation of genes and myogenesis. The purpose of this study was to investigate the effects of an acute bout of exhaustive resistance exercise on miR-206 expression in slow and fast twitch skeletal muscles in trained and untrained male wistar rats. Methods: This experimental study was conducted with the animal model. 30 male wistar rats, were assigned in three groups: control (n=6), traind (n=12) and untrained (n=12). 48 h after the last training session in trained group(Resistance training included weight lifting up on a vertical ladder for 8 weeks), trained and untrained groups performed an acute exhaustive bout of resistance exercise and were sacrificed in a 4 time zone. Expression of miR-206 was measured by Real time – PCR technique. The differences between variables were determined by one way ANOVA method. Results: statistical analysis by one-way ANOVA showed that between trained and untrained groups in FHL and Sol muscles there was a significant difference (p=0.05) statistically. Also in both groups expression of miR-206 in FHL muscle elevated and in Sol muscle decreased. Conclusion: The findings showed that response of miR-206 to one bout resistance exercise with and without adaptation to training in fast and slow muscles is different.